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Table 2 List of 15 genes significantly differentially expressed at the P < 0.001 level between BTB-infected cattle (n = 6) and control cattle (n = 6) from the BOTL-5 microarray data

From: Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease

Array feature/Clone ID Gene symbol Gene name Gene ontology (GO) function/s Infected vs control animal relative expression
NBFGC_AW656075 NCOR1 Nuclear receptor co-repressor 1 DNA binding, protein binding, transcription corepressor activity -2.12
NBFGC_BF604459 PPP2R5B PP2A protein phosphatase 2A B56-beta Protein phosphatase type 2A regulator activity 1.43
BOTL0100001XG10R UCP2 Uncoupling protein 2 (UCP2) (mitochondrial, proton carrier) Binding, transporter activity -1.80
BOTL0100002XD04R UNC84B Unc-84 homolog B Microtubule binding -1.58
BOTL0100003XB12R ZDHHC19 Zinc finger, DHHC-type containing 19 Acyltransferase activity, metal ion binding, transferase activity, zinc ion binding 1.94
BOTL0100003XF01R NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Protein binding, transcription factor activity -2.28
BOTL0100004XD01R GAN Giant axonal neuropathy (gigaxonin) Protein binding -1.41
BOTL0100005XF07R SFPQ Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) DNA, RNA, nucleotide and protein binding -1.67
BOTL0100007_C06 NRM Nurim Nuclear envelope membrane protein -3.07
BOTL0100013_F01 - Unknown Unknown – limited similarity to Formin 2 -1.59
Fibroblast growth factor receptor 1 FGFR1 Fibroblast growth factor receptor 1 ATP, nucleotide and protein binding. Receptor and tranferase activity. -2.77
NBFGC_BE479784 TBK1 TANK-binding kinase 1 ATP and nucleotide binding. Protein kinase and signal transducer activity. -1.63
NBFGC_BE682784 28S 28S ribosomal RNA gene Protein biosynthesis 1.52
NBFGC_BF076990 GPR98 G protein-coupled receptor 98 G-protein coupled receptor activity, calcium ion binding 2.07
Neuropilin 1 (NRP1) NRP1 Neuropilin 1 Receptor activity, vascular endothelial growth factor receptor activity -2.98
  1. Clone IDs were obtained from the Center for Animal Functional Genomics (CAFG) website [51].