Table 2 Putative SmINSIG interaction partners or possible downstream pathway genes in schistosomes, according to the INSIG functions and pathways described in the literature for other organisms
Protein/gene | Accession [species] | Function |
|---|---|---|
Acetyl-CoA acetyltransferase | [GenBank: AAX26758.2]/[GenBank: AAX30459.1] [S. japonicum] C611014.1* [S. mansoni] | Mevalonate pathway |
HMG-CoA reductase | [Swissprot: P16237] [S. mansoni] | Mevalonate pathway |
Mevalonate kinase | C608152.1* [S. mansoni] | Mevalonate pathway |
P-Mevalonate kinase | [GenBank: AAW26333.1] [S. japonicum] C608797.1* [S. mansoni] | Mevalonate pathway |
Mevalonate diphosphate decarboxylase | C608650.1* [S. mansoni] | Mevalonate pathway |
IPP isomerase | [GenBank: AAX26888.1] [S. japonicum] | Mevalonate pathway |
gp78 Autocrine motility factor receptor (AMF receptor) | C609954.1*/C608624.1* [S. mansoni] | HMG-CoA reductase degradation |
SCAP | C714360.1* [S. mansoni] | SREBP processing |
Acetyl-CoA synthetase | C718554.1* [S. mansoni] [GenBank: AAX27415.2] [S. japonicum] | Fatty acid synthesis |
Acetyl/Propionyl-CoA carboxylase | C611533.1* [S. mansoni] [GenBank: AAX27462.2] [S. japonicum] | Fatty acid synthesis |