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Table 2 Genes down-regulated in Parp-1-/- ES cells

From: Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

 

Fold changea)

   

Accession No.

W vs H

J1 vs 210-58

J1 vs 226-47

Symbol

Chromosome

Gene description

Cell cycle/cell proliferation/cell death

      

AW122355

3.2

5.2

2.3

Prkcbp1

2

Protein kinase C binding protein 1

AF067395

2.9

2.9

2.9

Bnip3l

14

BCL2/adenovirus E1B 19 kDa-interacting protein

AI842277

2.7

2.3

3.2

Igfbp3

11

Insulin-like growth factor binding protein 3

U95826

2.2

2.5

1.9

Ccng2

5

Cyclin G2

Cell structure/cell adhesion

      

U16741

4.1

6.3

3.1

Capza2

6

Capping protein (actin filament) muscle Z-line, alpha 2

AI132380

3.6

3.1

4.3

Fndc3a

14

Fibronectin type III domain containing 3a

AI505453

2.9

2.5

3.4

Myh9

15

Myosin, heavy polypeptide 9, non-muscle

AW208938

2.4

3.2

2.0

Pkp2

16

Plakophilin 2

M76124

2.4

2.2

2.6

Tacstd1

17

Tumor-associated calcium signal transducer 1

Metabolism

      

U73820

5.5

5.2

5.8

Galnt1

18

Polypeptide GalNAc transferase-T1 (ppGaNTase-T1)

AI841270

3.4

2.4

6.4

Gstm1

3

Glutathione S-transferase, mu1

AV308550

2.6

4.1

1.9

Piga

x

Phosphatidylinostitol glycan, class A

AI851912

2.3

2.2

2.5

Rps27

3

Ribosomal protein S27

AI852144

2.1

2.9

1.7

Pbef-pending

12

Pre-B-cell colony-enhancing factor

U65986

2.1

1.9

2.5

Anxa11

14

Annexin A11

D50264

2.1

1.4

4.1

Pigf

17

Phosphatidylinositol glycan, class F

AF031486

2.0

2.0

2.0

Sms

x

Spermidine synthase

AI845882

2.0

2.5

1.7

Acyp1

12

Acylphosphatase1, erythrocyte (common) type

Protein biosynthesis/degradation

      

AI852581

3.0

3.0

3.1

Ide

19

Insulin degradating enzyme

AI414051

3.0

1.8

9.1

Usp24

4

Ubiquitin specific protease 24

AW121012

2.9

2.8

2.8

Rnf19

15

Ring finger protein 19

X92665

2.9

2.5

3.4

Ube2e1

14

Ubiquitin-conjugating enzyme UbcM3

AW048882

2.2

2.8

1.8

Iars

13

Isoleucine-tRNA synthetase

AA867340

2.2

1.9

2.6

Psme4

11

Proteasome (prosome, macropain) activator subunit

AB024427

2.2

2.3

2.1

Rnf11

4

Ring finger protein 11

Signaling

      

AI846023

4.6

2.8

13.1

Arl7

1

ADP-ribosylation factor-like 7

AA260005

2.8

2.7

2.8

Pawr

10

PPKC, apoptosis, WT1, regulator

AI317205

2.6

2.4

2.7

Map3k1

13

Mitogen activated protein kinase kinase kinase 1

AF035644

2.3

2.0

2.7

Ptp4a2

4

Protein tyrosine phosphatase 4a2

M21019

2.3

1.9

2.9

Rras

7

Harvey rat sarcoma oncogene, subgroup R

AI194248

2.2

2.5

1.9

Csnk2a1

2

Casein kinase II, alpha 1 polypeptide

AI854006

2.0

2.0

2.1

Set

2

SET translocation

D83921

2.0

1.9

2.1

Ebaf

1

Endometrial bleeding associated factor

Transcription/replication

      

X14206

9.9

8.4

12.0

Adprt1

1

Poly(ADP-ribose) polymerase 1

M99167

3.0

6.2

2.0

Hnrpa1

15

Heterogeneous nuclear ribonucleoprotein A1

AW107922

2.8

3.7

2.2

Sox11

12

SRY box-containing gene 11

AI849135

2.5

2.5

2.5

Foxo3a

10

Forkhead box 03a

Y07836

2.5

2.3

2.8

Bhlhb2

6

Basic-helix-loop-helix domain containing, class B2

X74760

2.5

2.3

2.7

Notch3

17

Notch gene homolog 3, (Drosophila)

AI447783

2.1

2.4

1.9

Helb

10

Helicase(DNA) B

X94694

2.1

2.7

1.7

Tcfap2c

2

Transcription factor AP-2, gamma

AF077861

2.1

2.2

2.1

Id2

12

Inhibitor of DNA binding 2

AI605405

2.0

1.9

2.2

Phf13

4

PHD finger protein 13

D78382

2.0

1.7

2.6

Tob1

11

Transducer of ErbB2.1

Transport

      

AV356315

4.1

5.5

3.3

Lman1

18

Lectin, mannose-binding, 1

AV298789

2.9

2.6

3.2

Ranbp5

14

Ran binding protein 5

D88315

2.2

2.2

2.2

Hiat1

3

Hippocampus abundant gene transcript 1

Unknown

      

AI845617

3.5

3.5

3.4

2610019A05Rik

11

Hypothetical protein

AI852287

3.2

3.3

3.2

Ankrd28

14

Ankyrin repeat domain 28

AI836771

3.0

2.8

3.3

2900008M13Rik

15

Unknown EST

AA684456

2.9

2.1

4.5

2310015N07Rik

7

Hypothetical protein

AI848435

2.8

1.9

4.8

C78339

13

Unknown EST

AW123157

2.7

2.5

3.1

1700051E09Rik

11

Hypothetical protein

AW124843

2.6

3.1

2.3

C85108

4

Unknown EST

AA710439

2.6

2.0

3.6

6230421P05Rik

16

Unknown EST

AI853444

2.5

1.8

3.9

2610042L04Rik

14

Hypothetical protein

AI853444

2.2

2.1

2.3

2610042L04Rik

14

Hypothetical protein

AW121353

2.1

1.6

3.1

Lrrc8

2

Luecine rich repeat containing 8

AI037493

2.1

1.5

3.4

Tbc1d15

10

TBC1 domain family, member 15

AI461803

2.1

2.2

1.9

1300006C19Rik

9

Hypothetical protein

AW049969

2.0

2.0

2.1

C330005L02Rik

9

Hypothetical protein

AI847483

2.0

2.0

2.0

Tmem41b

7

Transmembrane protein 41B

  1. a)W, wild-type cells (J1); H, Parp-1-/- ES cells (210-58 and 226-47).
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BMC Genomics

ISSN: 1471-2164

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