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Table 4 Genes down- and up-regulated in Parp-1-/- livers

From: Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

  

Fold changea)

   
 

Accession No.

W vs H

W1 vs H1

W1 vs H2

W2 vs H1

W2 vs H2

Symbol

Chromosome

Gene description

Down-regulated

         

Cell structure/cell adhesion

         
 

AA867778

2.1

2.4

2.6

1.7

1.8

Actn1

12

Actinin, alpha 1

Cell cycle/cell proliferation/cell death

         
 

AJ223782

2.0

1.8

1.7

2.5

2.3

Sept7

9

Septin7 (Cdc10)

Immune response

         
 

X05475

2.1

2.5

1.8

2.6

1.9

C9

15

Complement component C9

Metabolism

         
 

L42996

3.0

1.7

3.7

2.7

5.8

Dbt

3

Nuclear-encoded mitochondrial acyltransferase

 

AF026075

2.4

1.8

4.3

1.7

4.0

Sult3a1

10

Sulfotransferase-related protein (SULT-X2)

Protein biosynthesis/degradation

         
 

M27347

3.2

3.4

3.2

3.1

3.0

Ela1

15

P6-5 gene, 3' end (elastase 1)

Signaling

         
 

AI563623

2.3

2.9

1.9

2.9

1.8

Pkn2

3

Protein kinase N2

Transcription/replication

         
 

AF010405

4.9

6.8

3.2

8.5

4.1

Hfh-1L

13

HNF-3/forkhead homolog 1 like

 

L20450

3.7

3.1

2.7

5.0

4.3

Zfp97

17

Zinc finger protein 97

 

AW048355

2.1

1.6

1.9

2.3

2.8

Phf17

3

PHD finger protein 17

 

AI848996

2.1

2.2

2.3

2.0

2.1

Dhx40

11

DEAH box polypeptide 40

 

AW123909

2.1

1.5

1.9

2.2

2.9

Rbpms

8

RNA binding protein gene with multiple splicing

Transport

         
 

D86066

3.2

2.3

4.4

2.6

4.8

Rab5ep-pending

11

Rabaptin-5

Others

         
 

AI835016

2.4

2.1

2.3

2.5

2.7

Hps4

5

Light ear protein (1e)

Unknown

         
 

AI848841

2.1

2.2

1.6

2.7

2.0

A230106A15Rik

13

Unknown

Up-regulated

 

H vs W

H1 vs W1

H1 vs W2

H2 vs W1

H2 vs W2

   

Cell cycle/cell proliferation/cell death

         
 

X95280

3.0

2.8

2.7

3.4

3.2

G0s2

1

GOS2-like protein

Cell structure/cell adhesion

         
 

AI132491

2.1

1.9

2.6

1.6

2.2

Bysl

17

Bystin-like

Immune response

         
 

J00475

3.1

9.2

2.8

4.2

1.3

Iga

12

Germline IgH chain gene, DJC region-segment D-FL16.1

Metabolism

         
 

M63245

3.2

2.8

4.0

2.6

3.7

Alas1

9

Amino levulinate synthase (ALAS-H)

 

AW121625

2.5

2.8

2.4

2.6

2.3

Galnt11

5

Polypeptide GalNAc transferase 11

 

Y15003

2.1

1.8

1.9

2.3

2.5

St3gal5

6

Beta-galactoside alpha-2,3-sialyltransferase 5

Signaling

         
 

L76567

4.1

1.8

2.3

5.5

7.0

Shp1

4

Shp gene

Transcription/replication

         
 

AI553024

2.4

2.4

1.5

3.8

2.4

Zbtb16

9

Zinc finger and BTB domain containing 16

Unknown

         
 

AI042964

7.1

7.1

8.4

5.9

7.1

0610005C13Rik

7

Hypothetical protein

 

AI593759

3.7

3.0

4.0

3.4

4.6

9530051K01Rik

7

Hypothetical protein

 

AI019679

2.3

10.0

1.4

9.4

1.3

1100001G20Rik

11

Hypothetical protein

  1. a) W, Parp-+/+ livers from two animals (W1 & W2): H, Parp-1-/- livers from two animals (H1 & H2).
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