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Table 2 Differentially expressed genes of F3- or LPS-induced THP-1 cells using oligonucleotide microarray

From: Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction

Pathway

Gene

Gene Description

Fold Change

   

F3–6 hr/C

F3–24 hr/C

LPS-24 hr/C

Induction of apoptosis through DR3 and DR4/5 Death Receptors

TNFSF10*

tumor necrosis factor (ligand) superfamily, member 10

9.9

10.1

18.4

 

TNFRSF10B*

tumor necrosis factor receptor superfamily, member 10b

2.1

2.4

2.8

 

CASP8*

caspase 8, apoptosis-related cysteine peptidase

1.3

1.3

1.6

 

CASP10*

caspase 10, apoptosis-related cysteine peptidase

2.9

2.6

2.6

 

BID

BH3 interacting domain death agonist

4.3

1.3

2.2

 

BCL2*

B-cell CLL/lymphoma 2

0.6

0.7

0.7

 

CYCS

cytochrome c, somatic

1.0

0.7

0.8

 

APAF1

apoptotic peptidase activating factor

0.9

1.0

1.0

 

CASP9

caspase 9, apoptosis-related cysteine peptidase

0.9

1.0

1.0

 

CFLAR

CASP8 and FADD-like apoptosis regulator

3.1

2.3

4.2

 

FADD*

Fas (TNFRSF6)-associated via death domain

0.8

1.0

0.9

 

TRADD*

TNFRSF1A-associated via death domain

2.1

2.0

1.3

 

TRAF2

TNF receptor-associated factor 2

1.1

0.9

0.6

 

RIPK1*

receptor (TNFRSF)-interacting serine-threonine kinase 1

1.7

1.1

1.7

 

MAP3K14

mitogen-activated protein kinase kinase kinase 14

1.6

1.1

1.9

 

CHUK*

conserved helix-loop-helix ubiquitous kinase

0.9

0.8

1.0

 

NFKBIA*

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

12.6

6.6

10.5

 

NFKB1*

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

5.2

2.2

2.8

 

BIRC2*

baculoviral IAP repeat-containing 2

1.5

1.0

1.7

 

CASP3*

caspase 3, apoptosis-related cysteine peptidase

1.2

1.3

1.3

 

CASP7*

caspase 7, apoptosis-related cysteine peptidase

3.4

2.1

2.7

 

DFFB

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

0.4

1.0

0.5

 

DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

0.8

1.1

0.9

 

CASP6*

caspase 6, apoptosis-related cysteine peptidase

0.5

0.5

0.4

 

LMNA

lamin A/C

1.6

1.6

1.6

 

GAS2

growth arrest-specific 2

0.8

1.1

1.5

 

SPTAN1

spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

1.3

1.3

0.9

NF-kB Signaling Pathway

TNFRSF1A

tumor necrosis factor receptor superfamily, member 1A

1.6

1.5

1.3

 

FADD*

Fas (TNFRSF6)-associated via death domain

0.8

1.1

0.9

 

TRADD*

TNFRSF1A-associated via death domain

2.1

2.0

1.3

 

RIPK1*

receptor (TNFRSF)-interacting serine-threonine kinase 1

1.7

1.1

1.7

 

TRAF6

TNF receptor-associated factor 6

1.3

1.1

1.1

 

TLR4

toll-like receptor 4

1.3

1.2

0.9

 

IRAK1

interleukin-1 receptor-associated kinase 1

0.6

0.8

0.6

 

MYD88

myeloid differentiation primary response gene (88)

4.0

2.6

2.7

 

IL1A

interleukin 1, alpha

3.2

1.2

2.4

 

IL1B

interleukin 1, beta

63.2

17.5

53.1

 

MAP3K7IP1

mitogen-activated protein kinase kinase kinase 7 interacting protein 1

0.7

1.0

0.8

 

MAP3K7

mitogen-activated protein kinase kinase kinase 7

1.1

0.9

0.9

 

CHUK*

conserved helix-loop-helix ubiquitous kinase

0.9

0.8

1.0

 

MAP3K1

mitogen-activated protein kinase kinase kinase 1

0.8

1.2

1.1

 

MAP3K14

mitogen-activated protein kinase kinase kinase 14

1.6

1.1

1.9

 

IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

0.8

1.0

0.9

 

IKBKG

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

1.2

1.2

1.2

 

NFKBIA*

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

12.6

6.6

10.5

 

NFKB1*

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

5.2

2.2

2.8

 

RELA

v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)

1.0

1.1

1.1

TNFR2 Signaling Pathway

LTA

lymphotoxin alpha

1.4

1.7

1.2

 

TNFRSF1B

tumor necrosis factor receptor superfamily, member 1B

4.3

3.5

4.1

 

RIPK1*

receptor (TNFRSF)-interacting serine-threonine kinase 1

1.7

1.1

1.7

 

TRAF1

TNF receptor-associated factor 1

5.9

4.4

7.9

 

TRAF2

TNF receptor-associated factor 2

1.1

0.9

0.6

 

TRAF3

TNF receptor-associated factor 3

1.3

1.1

1.2

 

TANK

TRAF family member-associated NFKB activator

2.3

1.9

2.9

 

MAP3K14

mitogen-activated protein kinase kinase kinase 14

1.6

1.1

1.9

 

MAP3K1

mitogen-activated protein kinase kinase kinase 1

0.8

1.1

1.1

 

DUSP1

dual specificity phosphatase 1

2.7

1.5

4.0

 

CHUK*

conserved helix-loop-helix ubiquitous kinase

0.9

0.8

1.0

 

IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

0.8

0.9

0.9

 

IKBKG

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

1.2

1.2

1.2

 

IKBKAP

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

0.9

1.0

0.7

 

TNFAIP3

tumor necrosis factor, alpha-induced protein 3

12.7

5.4

11.4

 

NFKBIA*

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

12.2

6.6

10.5

 

NFKB1*

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

5.2

2.2

2.8

Toll-like Receptor Pathway

TLR2

toll-like receptor 2

1.2

2.1

2.6

 

CD14

CD14 antigen ; CD14 antigen

0.5

15.2

16.9

 

MYD88

myeloid differentiation primary response gene (88)

4.0

2.6

2.7

 

TLR4

toll-like receptor 4

1.3

1.2

0.9

 

LY96

lymphocyte antigen 96

0.6

5.3

6.3

 

TOLLIP

toll interacting protein

1.0

1.1

1.2

 

IRAK1

interleukin-1 receptor-associated kinase 1

0.6

0.8

0.6

 

TRAF6

TNF receptor-associated factor 6

1.3

1.1

1.1

 

EIF2AK2

eukaryotic translation initiation factor 2-alpha kinase 2

5.1

4.0

4.5

 

SITPEC

signaling intermediate in Toll pathway, evolutionarily conserved

0.8

0.7

0.4

 

MAP3K1

mitogen-activated protein kinase kinase kinase 1

0.8

1.2

1.1

 

CHUK*

conserved helix-loop-helix ubiquitous kinase

0.9

0.8

1.0

 

IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

0.8

1.0

0.9

 

IKBKG

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

1.2

1.2

1.2

 

NFKBIA*

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

12.6

6.6

10.5

 

MAP3K7

mitogen-activated protein kinase kinase kinase 7

1.1

0.9

1.0

 

MAP3K7IP2

mitogen-activated protein kinase kinase kinase 7 interacting protein 2

1.6

1.2

1.4

 

MAP3K7IP1

mitogen-activated protein kinase kinase kinase 7 interacting protein 1

0.7

1.0

0.8

 

MAP2K3

mitogen-activated protein kinase kinase 3

2.2

1.5

1.9

 

MAP2K6

mitogen-activated protein kinase kinase 6

0.7

1.1

0.8

 

MAPK14

mitogen-activated protein kinase 14

0.6

0.9

0.8

 

MAP2K4

mitogen-activated protein kinase kinase 4

0.9

1.0

1.0

 

MAPK8

mitogen-activated protein kinase 8

2.6

1.2

1.5

 

JUN

v-jun sarcoma virus 17 oncogene homolog (avian)

7.9

1.3

2.6

 

FOS

v-fos FBJ murine osteosarcoma viral oncogene homolog

1.5

2.3

1.8

 

ELK1

ELK1, member of ETS oncogene family

0.9

1.4

1.5

  1. *These genes have been validated by Q-PCR.
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BMC Genomics

ISSN: 1471-2164

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