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Table 3 Summary of differentially expressed genes between the suicide completer group vs. non-suicide group in schizophrenia with fold change relative to non-suicide group.

From: Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex

Gene symbol

Description

FC1

FDR2

P/A call3

GJA1

gap junction protein, alpha 1, 43 kDa (connexin 43)

-2.0

0.02

P

MT1X

metallothionein 1X

-1.9

0.04

P

MT1M

metallothionein 1M

-1.9

0.06

P

AGXT2L1

alanine-glyoxylate aminotransferase 2-like 1

-1.9

0.03

P

SDC4

syndecan 4 (amphiglycan, ryudocan)

-1.7

0.01

P

SOX9

SRY (sex determining region Y)-box 9

-1.7

0.02

P

NTRK2

neurotrophic tyrosine kinase, receptor, type 2

-1.7

0.02

P

HSPB1

heat shock 27 kDa protein 1

-1.7

0.04

P

EIF5A

eukaryotic translation initiation factor 5A

-1.7

0.06

P

EFEMP1

EGF-containing fibulin-like extracellular matrix protein 1

-1.6

0.04

P

ID4

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

-1.6

0.02

P

APOE

apolipoprotein E

-1.6

0.03

P

PLSCR4

phospholipid scramblase 4

-1.6

0.03

P

AGT

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

-1.6

0.02

P

TUBB2B

tubulin, beta 2B

-1.5

0.04

P

MT1E

metallothionein 1E (functional)

-1.5

0.03

P

FAM107A

family with sequence similarity 107, member A

-1.5

0.03

P

SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

-1.5

0.05

P

GLUL

glutamate-ammonia ligase (glutamine synthetase)

-1.5

0.04

P

ALDH1L1

aldehyde dehydrogenase 1 family, member L1

-1.5

0.02

P

DDIT4

DNA-damage-inducible transcript 4

-1.5

0.04

P

MT1G

metallothionein 1G

-1.5

0.04

P

SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

-1.5

0.08

P

PPAP2B

phosphatidic acid phosphatase type 2B

-1.5

0.05

P

EMX2

empty spiracles homolog 2 (Drosophila)

-1.5

0.05

P

TP53BP2

tumor protein p53 binding protein, 2

-1.5

0.03

P

MT1H

metallothionein 1H

-1.5

0.02

P

APOLD1

apolipoprotein L domain containing 1

-1.4

0.08

P

FGFR3

fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)

-1.4

0.03

P

FXYD1

FXYD domain containing ion transport regulator 1 (phospholemman)

-1.4

0.00

P

NOTCH2

Notch homolog 2 (Drosophila)

-1.4

0.03

P

METTL7A

methyltransferase like 7A

-1.4

0.05

P

SLC14A1

solute carrier family 14 (urea transporter), member 1 (Kidd blood group)

-1.4

0.06

P

BBOX1

butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1

-1.4

0.03

P

MT1F

metallothionein 1F (functional)

-1.4

0.05

P

EPHX1

epoxide hydrolase 1, microsomal (xenobiotic)

-1.4

0.02

P

SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

-1.4

0.05

P

TPD52L1

tumor protein D52-like 1

-1.4

0.02

P

RHOBTB3

Rho-related BTB domain containing 3

-1.4

0.05

P

VIL2

villin 2 (ezrin)

-1.4

0.03

P

NDRG2

NDRG family member 2

-1.4

0.06

P

CLDN10

claudin 10

-1.4

0.06

P

NTSR2

neurotensin receptor 2

-1.4

0.03

A

ITPKB

inositol 1,4,5-trisphosphate 3-kinase B

-1.4

0.10

P

SDC2

syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)

-1.4

0.03

P

IL17RB

interleukin 17 receptor B

-1.3

0.03

P

SPON1

spondin 1, extracellular matrix protein

-1.3

0.02

P

LOC645745

metallothionein 1H-like protein

-1.3

0.03

P

ITGB4

integrin, beta 4

-1.3

0.03

P

MLC1

megalencephalic leukoencephalopathy with subcortical cysts 1

-1.3

0.05

P

ATP1A2

ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide

-1.3

0.05

P

RAB31

RAB31, member RAS oncogene family

-1.3

0.05

P

ATP1B2

ATPase, Na+/K+ transporting, beta 2 polypeptide

-1.3

0.05

P

AHCYL1

S-adenosylhomocysteine hydrolase-like 1

-1.3

0.03

P

CX3CR1

chemokine (C-X3-C motif) receptor 1

2.1

0.02

P

C3

complement component 3

1.6

0.02

P

CRH

corticotropin releasing hormone

1.6

0.05

P

ABCG2

ATP-binding cassette, sub-family G (WHITE), member 2

1.5

0.03

P

DUSP6

dual specificity phosphatase 6

1.5

0.04

P

NPY

neuropeptide Y

1.4

0.03

P

SLC25A23

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

1.4

0.03

A

LAPTM5

lysosomal associated multispanning membrane protein 5

1.4

0.03

P

TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

1.4

0.01

P

TYROBP

TYRO protein tyrosine kinase binding protein

1.4

0.03

P

CD74

CD74 molecule, major histocompatibility complex, class II invariant chain

1.4

0.03

P

P2RY13

purinergic receptor P2Y, G-protein coupled, 13

1.3

0.02

A

CSF1R

colony stimulating factor 1 receptor

1.3

0.03

P

HLA-DRA

major histocompatibility complex, class II, DR alpha

1.3

0.04

A

HLA-DPA1

major histocompatibility complex, class II, DP alpha 1

1.3

0.05

P

A2M

alpha-2-macroglobulin

1.3

0.03

P

  1. 1FC represents ratio of geometric means between suicides vs. non-suicide.
  2. 2 P-values were adjusted by FDR.
  3. 3Absent (A) or Present (P) detection call by MAS5 statistical algorithm
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BMC Genomics

ISSN: 1471-2164

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