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Table 1 Frequency overlap between p68 and p72 coexpressed genes.

From: Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis

Gene

p68 %

p72 %

Function

Gene Name

TIA1

26%

16%

Splicing

cytotoxic granule-associated RNA-binding protein

SFRS5

37%

21%

Splicing

splicing factor, arginine/serine-rich, 5

SFPQ

42%

47%

Splicing

splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

SF1

37%

26%

Splicing

splicing factor 1

MBNL1

53%

32%

Alternative Splicing

muscleblind-like protein(Triplet-expansion RNA-binding protein)

HNRPH1

47%

32%

Splicing

heterogeneous nuclear ribonucleoprotein H (hnRNP H)

CROP

21%

37%

SR Protein -Splicing?

cisplatin resistance-associated overexpressed protein (LUC7A)

CPSF2

42%

21%

Splicing

cleavage and polyadenylation specificity factor

C6orf111

32%

32%

Splicing

splicing factor, arginine/serine-rich 130

FLJ12529

21%

16%

Splicing

pre-mRNA cleavage factor I, 59 kDa subunit

DDX5

100%

26%

Splicing/Transcription

p68 DEAD-box RNA helicase

DDX17

26%

100%

Splicing/Transcription

p72 DEAD-box RNA helicase

PAPOLA

26%

21%

Transcription/Splicing

poly(A) polymerase alpha

ILF3

26%

21%

Transcription/Splicing

NFAR1/NF-90/subunit of NFAT transcription factor

PNN

16%

21%

Transcription/Splicing

pinin(DRS)

XBP1

26%

21%

Transcription/ER-alpha pathway

X-box binding protein 1

THRAP2

32%

21%

Transcription?

thyroid hormone receptor associated protein 2

RORA

26%

26%

Transcription

RAR-related orphan receptor alpha

PTMA

21%

16%

Transcription

prothymosin, alpha (gene sequence 28)

DHX9

47%

32%

Transcription

RNA Helicase A/DEAH (Asp-Glu-Ala-His) box polypeptide 9

BMI1

21%

16%

Transcription Silencing

B lymphoma Mo-MLV insertion region (mouse) [Polycomb complex protein BMI-1]

SMARCA2

16%

21%

Transcription

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

HIF1A

16%

16%

Transcription

hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

MAP3K7IP2

26%

21%

Signal Transduction/Transcription

mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (TAB2)

PRKAR1A

47%

32%

Signal Transduction

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

PIK3R1

21%

21%

Signal Transduction

phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)

HIPK2

32%

16%

Signal Transduction/Apoptosis

homeodomain interacting protein kinase 2

DNAJC3

21%

16%

Signal Transduction

DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor)

CSNK1A1

32%

21%

Signal Transduction

casein kinase 1, alpha 1

GNAS

21%

21%

Receptor-Stimulated G-Protein

guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1

ABI2

26%

21%

Cytoskeleton

Abl-interactor 2 (Abelson interactor 2)

ARPC3

21%

26%

Cytoskeleton

actin related protein 2/3 complex, subunit 3, 21kDa (p21-ARC)

FNBP4

26%

21%

Cytoskeleton?

formin binding protein 4

WASPIP

16%

16%

Cytoskeleton

Wiskott-Aldrich syndrome protein interacting protein

UTRN

16%

21%

Cytoskeleton

utrophin (homologous to dystrophin)

RAP2A

16%

16%

Cytoskeleton?

RAP2A, member of RAS oncogene family

NEDD5

16%

21%

Cytoskeleton/cell-cycle?

septin 2 (GTP-binding protein family)

ACTB

16%

26%

Cytoskeleton

beta actin

MAPRE2

16%

16%

Cytoskeleton

microtubule-associated protein, RP/EB family, member 2

SDCBP

21%

21%

Scaffold Protein

syndecan binding protein (syntenin)

HNRPU

42%

32%

Nuclear Matrix Attachment

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

XPO1

26%

21%

Nuclear Export

exportin 1 (CRM1 homolog, yeast)

TNPO1

26%

32%

Nuclear Import

transportin 1

NUP133

26%

16%

Nuclear Pore

nuclear pore complex protein Nup133

ZFR

26%

21%

Nuclear RNA binding

zinc finger RNA binding protein

RAB5A

16%

16%

Endocytosis

RAB5A, member RAS oncogene family

RAB6A

68%

16%

Golgi-ER trafficking

RAB6A, member RAS oncogene family

GDI2

26%

26%

ER-golgi?(Interacts Rab6, above)

rab GDP-dissociation inhibitor, beta

EDEM1

21%

32%

Calnexin cycle/protein folding

ER degradation enhancer, mannosidase alpha-like 1

RAB14

32%

26%

Golgi-endosome trafficking

RAB14, member RAS oncogene family

PLEKHB2

26%

16%

post-golgi vesicle protein

pleckstrin homology domain containing, family B (evectins) member 2

TMP21

37%

37%

Trafficking

transmembrane trafficking protein

TRAM1

26%

16%

Protein Translocation

translocation associated membrane protein 1

SLC38A2

21%

21%

Amino acid transport

Solute carrier family 38, member 2

SLC25A5

26%

25%

ADP/ATP carrier protein

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

CGI-109

37%

16%

Protein transport?

hypothetical protein

USP9X

21%

16%

Ubiquitin

ubiquitin specific protease 9, X chromosome (Drosophila fat facets related)

UBE2J1

21%

32%

Ubiquitin

ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)

UBE3A

16%

21%

Ubiquitin

ubiquitin protein ligase E3A

BIRC6

16%

21%

Ubiquitin ligase/Anti-apoptosis

baculoviral IAP repeat-containing 6 (apollon)

BIRC2

32%

21%

Apoptosis-resistance

baculoviral IAP repeat-containing 2

PSMA2

21%

21%

Proteasome

proteasome (prosome, macropain) subunit, alpha type, 2

PIAS1

26%

21%

E3-SUMO Ligase

protein inhibitor of activated STAT, 1 (DEAD/H box-binding protein 1)

MAK3

21%

16%

N-acetyltransferase

Mak3 homolog (S. cerevisiae)

PFAAP5

21%

21%

Immune?

phosphonoformate immuno-associated protein 5

MCP

32%

26%

Immune

membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)

SMBP

26%

16%

Membrane protein

SM-11044 binding protein

MKLN1

21%

21%

Ischemic tolerance/Cell adhesion?

muskelin 1, intracellular mediator containing kelch motifs

ALDOA

26%

16%

Metabolism (glycolysis)

aldolase A, fructose-bisphosphate

IDI1

32%

26%

Metabolism

isopentenyl-diphosphate delta isomerase

CYB5-M

26%

16%

Metabolism

cytochrome b5 outer mitochondrial membrane precursor

GLO1

37%

21%

Metalloglutathione (GSH) transferase

glyoxalase I

EIF3S6

21%

16%

Translation

eukaryotic translation initiation factor 3, subunit 6 48kDa

EIF1AX

16%

21%

Translation

eukaryotic translation initiation factor 1A

PCBP2

16%

16%

Translation

poly(rC) binding protein 2 (hnRNPE2)

HNRPA2B1

32%

21%

Cell proliferation?

heterogeneous nuclear ribonucleoprotein A2/B1

CDK6

16%

16%

Cell-cycle

cyclin-dependent kinase 6

CCNE2

16%

16%

Cell-cycle

G1/S-specific cyclin E2

PUM2

26%

21%

Meiosis/RNA-binding

pumilio homolog 2 (Drosophila)

TRA2A

16%

26%

RNA-binding/?

transformer-2 alpha (putative MAPK activating protein PM24)

ATXN2

16%

21%

? (but has RNA motif)

ataxin 2

GTF2IP1

21%

26%

Pseudogene

general transcription factor II, i, pseudogene 1

H41

53%

26%

?

hypothetical protein

C19orf13

26%

37%

?

family with sequence similarity 61, member A (FAM61A)

CNIH

26%

26%

?

cornichon homolog (TGAM77)

LOC400986

26%

26%

?

protein immuno-reactive with anti-PTH polyclonal antibodies (HEM1)

ANKRD17

21%

21%

?

ankyrin repeat domain 17 (breast cancer antigen NY-BR-16)

RHOBTB3

16%

16%

? (GTPase)

Rho-related BTB domain containing 3

? - Unknown or unidentified gene product function

  1. 90 genes were identified to be both coexpressed with p68 and p72, and are arranged by function. For clarity all coexpressed gene products with a 30% or greater coexpression frequency correlation for either p68 or p72 are in bold.