From: Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis
Gene | p68 % | p72 % | Function | Gene Name |
---|---|---|---|---|
TIA1 | 26% | 16% | Splicing | cytotoxic granule-associated RNA-binding protein |
SFRS5 | 37% | 21% | Splicing | splicing factor, arginine/serine-rich, 5 |
SFPQ | 42% | 47% | Splicing | splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) |
SF1 | 37% | 26% | Splicing | splicing factor 1 |
MBNL1 | 53% | 32% | Alternative Splicing | muscleblind-like protein(Triplet-expansion RNA-binding protein) |
HNRPH1 | 47% | 32% | Splicing | heterogeneous nuclear ribonucleoprotein H (hnRNP H) |
CROP | 21% | 37% | SR Protein -Splicing? | cisplatin resistance-associated overexpressed protein (LUC7A) |
CPSF2 | 42% | 21% | Splicing | cleavage and polyadenylation specificity factor |
C6orf111 | 32% | 32% | Splicing | splicing factor, arginine/serine-rich 130 |
FLJ12529 | 21% | 16% | Splicing | pre-mRNA cleavage factor I, 59 kDa subunit |
DDX5 | 100% | 26% | Splicing/Transcription | p68 DEAD-box RNA helicase |
DDX17 | 26% | 100% | Splicing/Transcription | p72 DEAD-box RNA helicase |
PAPOLA | 26% | 21% | Transcription/Splicing | poly(A) polymerase alpha |
ILF3 | 26% | 21% | Transcription/Splicing | NFAR1/NF-90/subunit of NFAT transcription factor |
PNN | 16% | 21% | Transcription/Splicing | pinin(DRS) |
XBP1 | 26% | 21% | Transcription/ER-alpha pathway | X-box binding protein 1 |
THRAP2 | 32% | 21% | Transcription? | thyroid hormone receptor associated protein 2 |
RORA | 26% | 26% | Transcription | RAR-related orphan receptor alpha |
PTMA | 21% | 16% | Transcription | prothymosin, alpha (gene sequence 28) |
DHX9 | 47% | 32% | Transcription | RNA Helicase A/DEAH (Asp-Glu-Ala-His) box polypeptide 9 |
BMI1 | 21% | 16% | Transcription Silencing | B lymphoma Mo-MLV insertion region (mouse) [Polycomb complex protein BMI-1] |
SMARCA2 | 16% | 21% | Transcription | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
HIF1A | 16% | 16% | Transcription | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
MAP3K7IP2 | 26% | 21% | Signal Transduction/Transcription | mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (TAB2) |
PRKAR1A | 47% | 32% | Signal Transduction | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) |
PIK3R1 | 21% | 21% | Signal Transduction | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) |
HIPK2 | 32% | 16% | Signal Transduction/Apoptosis | homeodomain interacting protein kinase 2 |
DNAJC3 | 21% | 16% | Signal Transduction | DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) |
CSNK1A1 | 32% | 21% | Signal Transduction | casein kinase 1, alpha 1 |
GNAS | 21% | 21% | Receptor-Stimulated G-Protein | guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 |
ABI2 | 26% | 21% | Cytoskeleton | Abl-interactor 2 (Abelson interactor 2) |
ARPC3 | 21% | 26% | Cytoskeleton | actin related protein 2/3 complex, subunit 3, 21kDa (p21-ARC) |
FNBP4 | 26% | 21% | Cytoskeleton? | formin binding protein 4 |
WASPIP | 16% | 16% | Cytoskeleton | Wiskott-Aldrich syndrome protein interacting protein |
UTRN | 16% | 21% | Cytoskeleton | utrophin (homologous to dystrophin) |
RAP2A | 16% | 16% | Cytoskeleton? | RAP2A, member of RAS oncogene family |
NEDD5 | 16% | 21% | Cytoskeleton/cell-cycle? | septin 2 (GTP-binding protein family) |
ACTB | 16% | 26% | Cytoskeleton | beta actin |
MAPRE2 | 16% | 16% | Cytoskeleton | microtubule-associated protein, RP/EB family, member 2 |
SDCBP | 21% | 21% | Scaffold Protein | syndecan binding protein (syntenin) |
HNRPU | 42% | 32% | Nuclear Matrix Attachment | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
XPO1 | 26% | 21% | Nuclear Export | exportin 1 (CRM1 homolog, yeast) |
TNPO1 | 26% | 32% | Nuclear Import | transportin 1 |
NUP133 | 26% | 16% | Nuclear Pore | nuclear pore complex protein Nup133 |
ZFR | 26% | 21% | Nuclear RNA binding | zinc finger RNA binding protein |
RAB5A | 16% | 16% | Endocytosis | RAB5A, member RAS oncogene family |
RAB6A | 68% | 16% | Golgi-ER trafficking | RAB6A, member RAS oncogene family |
GDI2 | 26% | 26% | ER-golgi?(Interacts Rab6, above) | rab GDP-dissociation inhibitor, beta |
EDEM1 | 21% | 32% | Calnexin cycle/protein folding | ER degradation enhancer, mannosidase alpha-like 1 |
RAB14 | 32% | 26% | Golgi-endosome trafficking | RAB14, member RAS oncogene family |
PLEKHB2 | 26% | 16% | post-golgi vesicle protein | pleckstrin homology domain containing, family B (evectins) member 2 |
TMP21 | 37% | 37% | Trafficking | transmembrane trafficking protein |
TRAM1 | 26% | 16% | Protein Translocation | translocation associated membrane protein 1 |
SLC38A2 | 21% | 21% | Amino acid transport | Solute carrier family 38, member 2 |
SLC25A5 | 26% | 25% | ADP/ATP carrier protein | Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 |
CGI-109 | 37% | 16% | Protein transport? | hypothetical protein |
USP9X | 21% | 16% | Ubiquitin | ubiquitin specific protease 9, X chromosome (Drosophila fat facets related) |
UBE2J1 | 21% | 32% | Ubiquitin | ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) |
UBE3A | 16% | 21% | Ubiquitin | ubiquitin protein ligase E3A |
BIRC6 | 16% | 21% | Ubiquitin ligase/Anti-apoptosis | baculoviral IAP repeat-containing 6 (apollon) |
BIRC2 | 32% | 21% | Apoptosis-resistance | baculoviral IAP repeat-containing 2 |
PSMA2 | 21% | 21% | Proteasome | proteasome (prosome, macropain) subunit, alpha type, 2 |
PIAS1 | 26% | 21% | E3-SUMO Ligase | protein inhibitor of activated STAT, 1 (DEAD/H box-binding protein 1) |
MAK3 | 21% | 16% | N-acetyltransferase | Mak3 homolog (S. cerevisiae) |
PFAAP5 | 21% | 21% | Immune? | phosphonoformate immuno-associated protein 5 |
MCP | 32% | 26% | Immune | membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) |
SMBP | 26% | 16% | Membrane protein | SM-11044 binding protein |
MKLN1 | 21% | 21% | Ischemic tolerance/Cell adhesion? | muskelin 1, intracellular mediator containing kelch motifs |
ALDOA | 26% | 16% | Metabolism (glycolysis) | aldolase A, fructose-bisphosphate |
IDI1 | 32% | 26% | Metabolism | isopentenyl-diphosphate delta isomerase |
CYB5-M | 26% | 16% | Metabolism | cytochrome b5 outer mitochondrial membrane precursor |
GLO1 | 37% | 21% | Metalloglutathione (GSH) transferase | glyoxalase I |
EIF3S6 | 21% | 16% | Translation | eukaryotic translation initiation factor 3, subunit 6 48kDa |
EIF1AX | 16% | 21% | Translation | eukaryotic translation initiation factor 1A |
PCBP2 | 16% | 16% | Translation | poly(rC) binding protein 2 (hnRNPE2) |
HNRPA2B1 | 32% | 21% | Cell proliferation? | heterogeneous nuclear ribonucleoprotein A2/B1 |
CDK6 | 16% | 16% | Cell-cycle | cyclin-dependent kinase 6 |
CCNE2 | 16% | 16% | Cell-cycle | G1/S-specific cyclin E2 |
PUM2 | 26% | 21% | Meiosis/RNA-binding | pumilio homolog 2 (Drosophila) |
TRA2A | 16% | 26% | RNA-binding/? | transformer-2 alpha (putative MAPK activating protein PM24) |
ATXN2 | 16% | 21% | ? (but has RNA motif) | ataxin 2 |
GTF2IP1 | 21% | 26% | Pseudogene | general transcription factor II, i, pseudogene 1 |
H41 | 53% | 26% | ? | hypothetical protein |
C19orf13 | 26% | 37% | ? | family with sequence similarity 61, member A (FAM61A) |
CNIH | 26% | 26% | ? | cornichon homolog (TGAM77) |
LOC400986 | 26% | 26% | ? | protein immuno-reactive with anti-PTH polyclonal antibodies (HEM1) |
ANKRD17 | 21% | 21% | ? | ankyrin repeat domain 17 (breast cancer antigen NY-BR-16) |
RHOBTB3 | 16% | 16% | ? (GTPase) | Rho-related BTB domain containing 3 |
? - Unknown or unidentified gene product function |