Figure 1

Schematic gene structure of 3 analysed genes. Schema of the RefSeq, ESTs, exonic structure of new isoforms identified with the Cap-finder RACE of human retina mRNA and the genomic structure containing the TSSs indicated by arrows. Red Arrows indicate new retina TSSs. A) C1orf32. Transcripts in human retina: isoform a contains a new first exon located 2.7 kb downstream from previous TSS, isoform b presents a first exon 58,5 kb upstream the previous TSS. This second transcript defines an intron containing another transcribed locus in the opposite strand, the gene MAEL. B) CNGA3: Cap-finder RACE of human retina mRNA confirmed the presence of an untranslated exon localised 23,4 kb upstream of exon1. One isoform contains alternatively spliced variant of exon 0 (asterisk). C) RDH12: the schematic representation of EST from human retina shows two forms of the transcripts starting in a new retina TSS. These two isoforms contain two alternatively spliced variants of the second exon (asterisk).