Table 5 Genes From 228 Cluster With Conserved Sp1 Sites
Gene Name; Aliases | Symbol | Evidence Related to Sp-Like Factors | Reference |
|---|---|---|---|
5'-nucleotidase, cytosolic III | Nt5c3 | Unknown | |
Activating transcription factor 3 | Atf3 | Induced by deferroxamine treatment; Sp1 reg. unknown | Oncogene 26(2):284-9, 2007. |
Ankyrin repeat domain 37 | Ankrd37 | Unknown | |
Aquaporin 4 | Aqp4 | Promoter has consensus Sp1 sites | Genomics 50(3):373-7, 1998. |
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) | Atp7a | Unknown | |
ATP-binding cassette, sub-family G (WHITE), member 2 | Abcg2 | Several consensus Sp1 sites within minimal functional promoter | Biochim. Biophys. Acta. 1520(3):234-41, 2001. |
Axin 2 (conductin, axil) | Axin2 | Unknown | |
BCL2-like 11 (apoptosis facilitator) | Bcl2l11 | Bcl2l11 inc. with apoptosis; enrichment for Sp1/Sp3 sites | Biochim. Biophys. Acta 1693:167–176, 2004. |
Tubulin polymerization-promoting protein; Brain-specific protein p25 alpha | Tppp | Unknown | |
Calponin 3, acidic | Cnn3 | Unknown | |
Chemokine (C-C motif) ligand 20 | Ccl20 | Reg. by Sp1; MIP-3alpha | J. Biol. Chem. 278(2):875-84, 2003. |
Cytochrome B Reductase 1 | Cybrd1 | Unknown | |
Cytochrome P450, family 51, subfamily A, polypeptide 1 | Cyp51a1 | Sp1 maximizes sterol regulation of promoter | Molecular Endocrinology 16 (8): 1853–1863, 2002. |
DNA-damage-inducible transcript 4 | Ddit4 | Sp1 regulation; hypoxic induction | Pharm. Res. 21(5):736-41, 2004. |
Early growth response 1 | Egr1 | Binds and inhibits Sp1 | Am. J. Physiol. Renal Physiol. 284(6):F1216-25, 2003. |
Egr1 | Promoter has consensus Sp1 sites | Oncogene 6(5):867-71, 1991. | |
Egr1 | Sp1 activates Egr1 gene expression | J. Biol. Chem. 268(23):16949-57, 1993. | |
Egr1 | Sp1 and Egr1 bind similar GC rich | Biochem. Biophys. Res. Commun. 194(3):1475-82, 1993. | |
Ephrin A3 | Efna3 | Unknown | |
ERO1-like (S. cerevisiae); Endoplasmic oxidoreductin-1-like protein | Ero1l | Reg. by hypoxia and Df; Sp1 regulation unknown | Eur. J. Biochem. 270(10):2228-35, 2003. |
Farnesyltransferase, CAAX box, beta | Fntb | Unknown | |
Gap junction protein, beta 2, 26 kDa; Connexin 26 | Gjb2 | Human gene reg. by Sp1/Sp3 | Biochim. Biophys. Acta. 1443(1–2):169-81, 1998. |
Glutathione peroxidase 2 (gastrointestinal) | Gpx2 | Contains Sp1 elements | Gene 248(1–2):109-16, 2000. |
Heme oxygenase 1 | Hmox1 | Functional Sp1-like site present in PI3 kinase responsive region | Free Radic. Biol. Med. 15;41(2):247-61, 2006. |
Jumonji domain containing 1A | Jmjd1a | Unknown | |
Metallothionein 1A | Mt1a | Sp1 interacts with chicken Mt promoter | Comp. Biochem. Physiol. Biochem. Mol. Biol. 116(1):75–86, 1997. |
Mt1a | Sp1 interacts with mouse Mt1 promoter | Biochem. J. 323 (Pt 1):79–85, 1997. | |
Mt1a | Sp1 interacts with metal response element in Mt promoter | FEBS Lett. 416(3):254-8, 1997. | |
Mt1a | Sp1 interacts with Mt1 promoter | J. Neurosci. 20(14):5200-7, 2000. | |
Mt1a | Sp1 interacts with Mt1 promoter | Nucleic Acids Res. 31(23):6710-21, 2003. | |
Peripheral myelin protein 22 | Pmp22 | Unknown | |
Phosphoglycerate kinase 1 | Pgk1 | Sp1 interacts with promoter; In vivo footprinting | Genes Dev. 4(8):1277-87, 1990. |
Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | P4ha1 | Unknown | |
Proliferating cell nuclear antigen | Pcna | 3 conserved Sp1 sites present in murine promoter | DNA Seq. 2(3):181-91, 1991. |
Ras homolog gene family, member B | RhoB | Contains Sp1 sites | J. Biol. Chem. 272(49):30637-44, 1997. |
RhoB | Promoter contains consensus Sp1 sites | Biochem. Biophys. Res. Commun. 226(3):688-94, 1996. | |
Rictor; FYN binding protein (FYB-120/130) | Rictor | Unknown | |
Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | Spr | Promoter contains Sp1 sites | Biochem. Biophys. Res. Commun. 251(2):597–602, 1998. |
Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Slc11a2 | Promoter contains Sp1 sites | Blood Cells Mol. Dis. 24(2):199–215, 1998. |
Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | Slc6a6 | Promoter cloning paper | Adv. Exp. Med. Biol. 483:97–108, 2000. |
Syndecan 1 | Sdc1 | Promoter reg. by Sp1 factor(s) | J. Biol. Chem. 271(21):12532-41, 1996. |
TGFB-induced factor (TALE family homeobox) | Tgif | Unknown | |
TIMP metallopeptidase inhibitor 1 | Timp1 | Sp1 basal and hypoxic regulation | J. Cell. Biochem. 91(6):1260-8, 2004. |
Timp1 | Sp1 invovled in induction by TGF-beta | J. Cell. Physiol. 203(2):345-52, 2005. | |
Timp1 | Sp1 invovled in induction by TGF-beta | Mol. Cancer Res. 4(3):209-20, 2006. | |
Timp1 | Sp1 binding increased by leptin treatment | Mol. Endocrinol. 20(12):3376-88, 2006. | |
Transferrin receptor (p90, CD71) | Tfrc | Contains a GC rich region | Oncogene 21(52):7933-44, 2002. |
Tripartitie motif protein 27 | Trim27 | Sp1 involved in promoter activity | Biochem. Biophys. Res. Commun. 261(2):381-4, 1999. |
Tubulin-specific chaperone c | Tbcc | Unknown |