Figure 2

Domain organisation of the T. cruzi , T. brucei and L. major phosphatases. Domains are colour-coded according to the type of domain and grouped within phosphatase subfamilies. PTP, protein tyrosine phosphatase; DSP, dual-specificity phosphatase (crossed means pseudophosphatase); kinase, protein kinase domain (crossed means pseudokinase); TPR, Tetratricopeptide repeat; LRR, Leucine rich repeat; CaLB, Calcium lipid binding; GRAM, glucosyltransferases, Rab-like GTPases activators and myotubularins domain (plasma membrane protein-binding domain); FYVE, Fab1p/YOTB, Vac1p/EEA1 (PI3P binding domain); EF-hand, calcium binding domain; S/T phosphatase, serine/threonine phosphatase catalytic domain; FCP, CTD protein phosphatase. Note that many InterPro domains are variations representing the same biological function and sometimes they overlap. Only one domain is represented for these regions in this figure. Numbers of each domain type are listed for the kinetoplastids and '-' shows where one of the parasites lacks a particular architecture. ACR2/cdc25-like are included in the DSP group.