Table 1 DNA-binding TF-encoding genes in human, mouse and fugu genomes. The TFs were classified based on their DNA-binding domains using a classification scheme adapted from Messina et al. [1]
TF family | Human | Mouse | Fugu |
|---|---|---|---|
AP-2 | 5 | 5 | 6 |
ARID | 11 | 9 | 15 |
Beta-scaffold – CCAAT | 8 | 8 | 9 |
Beta-scaffold – MADS | 5 | 5 | 9 |
Beta-scaffold – p53 | 3 | 3 | 3 |
Beta-scaffold – RUNT | 3 | 3 | 5 |
Beta-scaffold – Others | 28 | 28 | 31 |
BHLH | 96 | 94 | 134 |
BZIP | 69 | 65 | 83 |
Dwarfin | 8 | 8 | 13 |
E2F | 11 | 9 | 11 |
Forkhead | 40 | 35 | 60 |
GCM | 2 | 2 | 2 |
Heat shock factor | 7 | 4 | 10 |
High mobility group box | 35 | 39 | 56 |
Homeobox | 221 | 199 | 282 |
Nuclear hormone receptor | 49 | 49 | 69 |
Paired box | 9 | 9 | 14 |
RFX | 6 | 6 | 7 |
T-box | 16 | 15 | 19 |
TEA | 4 | 4 | 5 |
Trp cluster – Ets | 29 | 29 | 31 |
Trp cluster – IRF | 9 | 9 | 15 |
Trp cluster – Myb | 11 | 11 | 13 |
ZnF-C2H2 | 472 | 290 | 254 |
ZnF-C3H | 6 | 4 | 7 |
ZnF-DM | 9 | 7 | 6 |
ZnF-GATA | 10 | 10 | 12 |
ZnF-Others | 61 | 55 | 73 |
Others (e.g., SAND, RBPSUH) | 84 | 72 | 74 |
Total | 1,327 | 1,086 | 1,328 |