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Table 3 Functional KEGG annotation of genes associated with resistance or susceptibility to CM

From: Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice

KEGG pathwaysa Percentage of significant CM genesb
Ribosome 13.3
Cell adhesion molecules (CAMs) 10.0
Antigen processing and presentation 8.3
Oxidative phosphorylation 6.7
Hematopoietic cell lineage 6.7
Leukocyte transendothelial migration 6.7
ECM-receptor interaction 6.7
Cytokine-cytokine receptor interaction 5.0
Glycolysis/Gluconeogenesis 5.0
Fructose and mannose metabolism 5.0
Regulation of actin cytoskeleton 5.0
T cell receptor signaling pathway 5.0
Jak-STAT signalling pathway 5.0
Axon guidance 5.0
Valine, leucine and isoleucine degradation 5.0
Focal adhesion 5.0
Tight junction 5.0
MAPK signaling pathway 3.3
B cell receptor signaling pathway 3.3
Tryptophan metabolism 3.3
Propanoate metabolism 3.3
Butanoate metabolism 3.3
Bile acid biosynthesis 3.3
Fatty acid metabolism 3.3
Adipocytokine signaling pathway 3.3
Neuroactive ligand-receptor interaction 3.3
Neurodegenerative Disorders 3.3
  1. a Only the KEGG pathways that contained at least two genes were represented.
  2. b Of the 177 significant CM genes, 60 genes were annotated.