TY - JOUR AU - Coussens, Anna K. AU - Wilkinson, Christopher R. AU - Hughes, Ian P. AU - Morris, C. Phillip AU - van Daal, Angela AU - Anderson, Peter J. AU - Powell, Barry C. PY - 2007 DA - 2007/12/12 TI - Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis JO - BMC Genomics SP - 458 VL - 8 IS - 1 AB - Craniosynostosis, the premature fusion of calvarial sutures, is a common craniofacial abnormality. Causative mutations in more than 10 genes have been identified, involving fibroblast growth factor, transforming growth factor beta, and Eph/ephrin signalling pathways. Mutations affect each human calvarial suture (coronal, sagittal, metopic, and lambdoid) differently, suggesting different gene expression patterns exist in each human suture. To better understand the molecular control of human suture morphogenesis we used microarray analysis to identify genes differentially expressed during suture fusion in children with craniosynostosis. Expression differences were also analysed between each unfused suture type, between sutures from syndromic and non-syndromic craniosynostosis patients, and between unfused sutures from individuals with and without craniosynostosis. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-8-458 DO - 10.1186/1471-2164-8-458 ID - Coussens2007 ER -