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Table 2 Significantly differentially expressed genes: unfused v fusing/fused sutures.

From: Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis

Gene GenBank Name Fold
MFAP4 NM_002404 microfibrillar-associated protein 4 16.50
IL11RA NM_004512 interleukin 11 receptor, alpha 5.90
RBP4 NM_006744 plasma retinol binding protein 4 37.38
AMPH NM_001635 amphiphysin 8.27
INHBA NM_002192 inhibin, beta A (activin A, activin AB alpha polypeptide) 6.94
C1QTNF3 BC016021 C1q and tumor necrosis factor related protein 3 20.25
PRELP BC032498 proline arginine-rich end leucine-rich repeat protein 10.65
HDHD1A NM_012080 haloacid dehalogenase-like hydrolase domain containing 1A -1.78
AGC1 NM_013227 aggrecan 1 (chondroitin sulfate proteoglycan 1) 6.16
ANGPTL2 NM_012098 angiopoietin-like 2 6.67
C1orf24 NM_052966 chromosome 1 open reading frame 24 2.04
FMOD NM_002023 fibromodulin 5.41
OLFM1 NM_006334 olfactomedin 1 2.55
FBLN1 NM_006486 fibulin 1 12.88
SSPN NM_005086 sarcospan 4.40
CYFIP2 BC026892 cytoplasmic FMR1 interacting protein 2 -2.68
MN1 NM_002430 meningioma 1 3.72
PTN NM_002825 pleiotrophin (osteoblast-specific factor 1) 6.25
EGFR NM_005228 epidermal growth factor receptor 2.71
TNN NM_022093 tenascin N 6.67
ADCY2 NM_020546 adenylate cyclase 2 (brain) 2.96
PDZRN3 NM_015009 PDZ domain containing RING finger 3 3.71
SPON1 BC041974 spondin 1, extracellular matrix protein 4.73
APP NM_000484 amyloid beta (A4) precursor protein 1.83
AUTS2 NM_015570 autism susceptibility candidate 2 1.94
GPC3 NM_004484 glypican 3 7.13
HAPLN1 NM_001884 hyaluronan and proteoglycan link protein 1 7.10
LHX6 NM_014368 LIM homeobox 6 -1.80
  1. Twenty-eight genes were identified as being significantly (false discovery rate adjusted P < 0.05) differentially expressed in unfused sutures compared to fused/fusing sutures. Genes are listed in order of significance with fold change relative to unfused sutures.