Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis

BMC Genomics

Table 2 Significantly differentially expressed genes: unfused v fusing/fused sutures.

Gene	GenBank	Name	Fold
MFAP4	NM_002404	microfibrillar-associated protein 4	16.50
IL11RA	NM_004512	interleukin 11 receptor, alpha	5.90
RBP4	NM_006744	plasma retinol binding protein 4	37.38
AMPH	NM_001635	amphiphysin	8.27
INHBA	NM_002192	inhibin, beta A (activin A, activin AB alpha polypeptide)	6.94
C1QTNF3	BC016021	C1q and tumor necrosis factor related protein 3	20.25
PRELP	BC032498	proline arginine-rich end leucine-rich repeat protein	10.65
HDHD1A	NM_012080	haloacid dehalogenase-like hydrolase domain containing 1A	-1.78
AGC1	NM_013227	aggrecan 1 (chondroitin sulfate proteoglycan 1)	6.16
ANGPTL2	NM_012098	angiopoietin-like 2	6.67
C1orf24	NM_052966	chromosome 1 open reading frame 24	2.04
FMOD	NM_002023	fibromodulin	5.41
OLFM1	NM_006334	olfactomedin 1	2.55
FBLN1	NM_006486	fibulin 1	12.88
SSPN	NM_005086	sarcospan	4.40
CYFIP2	BC026892	cytoplasmic FMR1 interacting protein 2	-2.68
MN1	NM_002430	meningioma 1	3.72
PTN	NM_002825	pleiotrophin (osteoblast-specific factor 1)	6.25
EGFR	NM_005228	epidermal growth factor receptor	2.71
TNN	NM_022093	tenascin N	6.67
ADCY2	NM_020546	adenylate cyclase 2 (brain)	2.96
PDZRN3	NM_015009	PDZ domain containing RING finger 3	3.71
SPON1	BC041974	spondin 1, extracellular matrix protein	4.73
APP	NM_000484	amyloid beta (A4) precursor protein	1.83
AUTS2	NM_015570	autism susceptibility candidate 2	1.94
GPC3	NM_004484	glypican 3	7.13
HAPLN1	NM_001884	hyaluronan and proteoglycan link protein 1	7.10
LHX6	NM_014368	LIM homeobox 6	-1.80

Twenty-eight genes were identified as being significantly (false discovery rate adjusted P < 0.05) differentially expressed in unfused sutures compared to fused/fusing sutures. Genes are listed in order of significance with fold change relative to unfused sutures.

ISSN: 1471-2164