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Table 4 Gene Ontology analysis: unfused compared to fused sutures

From: Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis

Biological process increased in sutures: Unfused Fused P-value
Cell adhesion 32   1.95 × 10-12
   Cell matrix adhesion 4   6.53 × 10-3
Cell communication    
   Cell surface receptor linked signal transduction 25   4.45 × 10-3
   Dopamine metabolism 2   6.63 × 10-4
   Phosphoinsitide-mediated signalling   8 4.58 × 10-3
Cell differentiation    
   Heme biosynthesis   3 6.96 × 10-3
   Lymphocyte differentiation   6 1.27 × 10-3
Cellular physiological process    
   Anion transport 11   4.92 × 10-6
   Cell cycle   42 4.72 × 10-5
   Cell motility 11   2.70 × 10-4
   Extracellular matrix organisation and biosynthesis 4   1.11 × 10-3
   Microtubule based process   10 7.35 × 10-3
   Regulation of phosphorylation 3   5.30 × 10-3
Morphogenesis 18   5.34 × 10-4
   Cellular morphogenesis 9   5.60 × 10-3
   Mesoderm formation 2   4.46 × 10-3
   Organ morphogenesis 8   7.46 × 10-3
Organ development 23   3.45 × 10-7
   Cartilage condensation 2   5.89 × 10-3
   Eye development 3   4.98 × 10-4
   Muscle development 6   2.52 × 10-3
   Skeletal development 11   1.18 × 10-6
Regulation of development    
   Negative regulation of development 3   2.28 × 10-3
Response to abiotic stimulus    
   Response to chemical stimulus   20 7.31 × 10-3
   Response to reactive oxygen species   3 5.21 × 10-3
Response to biotic stimulus   116 5.73 × 10-41
   Defence response to bacteria   11 5.2 x10-9
   Defence response to fungi   3 1.65 × 10-3
   Response to virus   7 9.11 × 10-3
   Immune response   100 1.61 × 10-34
   Humoral immune response   22 1.57 × 10-8
   Inflammatory response   23 3.08 × 10-7
  1. Classification of gene ontologies (GO) significantly over-represented (P < 0.01) for genes at least 2 fold differentially expressed between unfused and fused sutures, listed under level 3 GO category headings. Not all level three GO categories listed were significantly over-represented and thus do not have a P-value