Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis

BMC Genomics

Table 5 Linear correlation between microarray and qRT-PCR data.

Gene	Probe Set	Slope	Correlation
ANXA3	209369_at	0.881	0.978
WIF1	204712_at	0.850	0.982
CYFIP2	220999_s_at	0.785	0.748
PTN	211737_x_at	1.063	0.905
PRELP	204223_at	0.755	0.938
FMOD	202709_at	0.867	0.851
C1QTNF3 long isoform	220988_s_at	1.774	0.738
C1QTNF3 short isoform	220988_s_at	0.806	0.990
RBP4	219140_s_at	1.100	0.968
GCP3	209220_at	1.036	0.929
COL8A2	221900_at	1.261	0.854
COL3A1	215077_at	0.767	0.709
Average Correlation			0.896

The average correlation for all probe sets is approximately 90%, not including the correlation of the long isoform of C1QTNF3. The short isoform of C1QTNF3 had 99% correlation, indicating that the short and not the long isoform of C1QTNF3 is differentially expressed between unfused and fused sutures.

ISSN: 1471-2164