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Table 2 Selected categories of NeuroStem chip entries.

From: "NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells

Category

Functional role

Examples

I. Stemness

Recognized markers of stemness

Oct3/4, Nanog, Tdgf1

 

Candidate markers of stemness

Cpxm1, Hook1, Ddx21

 

Germ cell markers

Rif1, Bnc1, Bnc2

 

Hematopoietic stem cell markers

Hoxb4, Cdcp1, C1qr1

 

Mesenchymal stem cell marker

Bmpr1a, Bmpr2, Cd49a

II. Proliferation

Proliferation markers

Ki67, Pcna, Myc

 

Neural proliferation markers

Emx1, Gbx2

III. Development

Differentiation

Lifr, Ebaf, Lyar

 

   Neuronal differentiation

Ren, Rai1, Neurod2

 

Dopaminergic differentiation

Dlx1, Dlx2, Lmx1a

 

Neuronal maturation

Mecp2, Ebf3, Sox4

 

Neuronal process formation

Hmgb1, Rage

 

Axonal elongation and branching

Pi3, Map1b, Slit1

IV. Neural markers

Pan-neural markers

Gap43, Nfh, Eno2

 

Markers of dopaminergic neurons

Th, Aadc, Dat

 

Markers of cholinergic neurons

Ngf

 

Markers of spinal neurons

Hoxc6

 

Glial markers

S100β, Cd68

 

   Astrocyte markers

Gfap, Tapa1

 

   Oligodendrocyte markers

Mag, Mobp, Omg

V. Distinct markers

Normal tissues

 
 

   Liver

Gata6, G6pd, Fabp1

 

   Pancreas

Tff3, Sst, Pax4

 

   Skeletal muscle

Itga7, Dmd, Tnnt3

 

   Cardiac muscle

Nkx2.5, Anf, Myhca

 

   Smooth muscle

Actg2, Cnn1, Sm22α

 

   Endothelial cells

Flt1, Vwf, Pecam1

 

Blood cell subtypes

Cd4, Cd8, Cd19

 

Cancer cells

Maspin

 

   Pancreatic cancer

Kras2

 

   Colon cancer

Mina53

 

   Breast cancer

Klk7

 

   Prostatic cancer

Hpn, Mat8

 

   Lung cancer

Rab5a, Tp63

 

   Ovarian cancer

Mgb2

 

   Hodgkin's lymphoma

Ptp4a, Atf5, p21snft

VI. Relevant groups

Apoptosis-related

p53, Psip1, Birc2

 

Telomere-related

Tert, Terf2, Rap1

 

Antioxidants

Sod1, Sod2, Gpx1

 

Imprinted genes

Tseb3, Gnas1, Grb10

 

FZD group

Fzd1, Fzd3, Sfrp1

 

WNT group

Wnt1, Wnt7a, Wisp1

 

BMP group

Bmp1, Bmp2, Bambi

 

STAT group

Stat1, Stat3, Pias1

 

FGF group

Fgf1, Fgf2, Fgfr4

 

GDF group

Gdf2, Gdf3, Gdf9

 

Caspases group

Casp1, Casp2, Hsp70

 

Cyclins group

Ccna1, Ccnc, Cdk1

 

Kruppel-like group

Klf2, Klf9, Znf184

  1. Due to functional redundancy, individual genes may fit into more than one category.