Table 4 Disease-related proteins with counterparts in U. maydis
Protein | Function | MIPS ID¶ | Diseases | U. maydis* | S. cerevisiae* | Ref.** |
|---|---|---|---|---|---|---|
ACADM | acyl-CoA dehydrogenase | Um01049 | acyl-CoA dehydrogenase deficiency | 58.0 | 11.6 | [68] |
ACADS | acyl-CoA dehydrogenase | Um04833 | acyl-CoA dehydrogenase deficiency | 35.2 | 11.2 | [69] |
BZRP/PBR | Benzodiazepine receptor | Um06406 | Cancer | 27.4 | 10.1 | [70] |
CES1 | Carboxylesterase | Um06071 | Cancer | 27.6 | 9.3 | [71] |
CLPTM1 | unknown | Um02586 | Cleft lip development | 30.5 | 11.1 | [72] |
DDC | Dopa decarboxylase | Um06083 | Parkinsons | 34.7 | 11.0 | [73] |
DOCK3 | Dedicator of cytokinesis 3 | Um01178 | Attention deficit hyperactivity disorder | 23.1 | 12.3 | [74] |
EPHX1 | Epoxide hydrolase | Um01938 | Cancer | 36.6 | 10.1 | [74] |
GCDH | glutaryl-CoA dehydrogenase | Um01335 | glutaryl-CoA dehydrogenase deficiency | 54.1 | 13.9 | [75] |
HEXA | Hexosaminidase A | Um00695 | Tay-Sachs disease | 20.1 | 12.7 | [76] |
HMGCL | Methylglutaryl CoA lyase | Um02001 | methylglutaric CoA lyase deficiency | 43.6 | 11.4 | [77] |
PIMT/PCMT1 | Methyl-transferase | Um11483 | Type 1 diabetes | 48.9 | 9.3 | [78] |
PRSS16 | serine protease | Um10091 | Diabetes mellitus/susceptibility to autoimmunity | 20.7 | 6.6 | [79] |
UGCG | Glucosyl-ceramide synthase | Um04496 | induced apoptosis | 22.3 | 8.1 | [80] |