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Table 1 Genes up-regulated by sepsis in the lung of the baboons at 2, 8 and 24 hr post E. coli challenge

From: Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis

Gene Accession no.

Gene Product

Fold change compared to control

  

2 h

8 h

24 h

Cytokine or chemokine

NM_002089

chemokine (C-X-C motif) ligand 2 (CXCL2)

10.8

  

NM_004591

chemokine (C-C motif) ligand 20 (CCL20)

8.3

  

NM_000576

interleukin 1, beta (IL1B)

4.5

  

NM_005409

chemokine (C-X-C motif) ligand 11 (CXCL11)

4.4

10.5

 

NM_001565

chemokine (C-X-C motif) ligand 10 (CXCL10)

4.3

  

NM_002982

chemokine (C-C motif) ligand 2 (CCL2)

3.5

  

NM_002198

interferon regulatory factor 1 (IRF1)

3.0

3.8

 

NM_000600

interleukin 6 (interferon, beta 2) (IL6)

2.2

  

NM_002189

interleukin 15 receptor, alpha (IL15RA)

2.2

  

NM_002984

chemokine (C-C motif) ligand 4 (CCL4)

2.2

  

NM_000759

colony stimulating factor 3 (granulocyte) (CSF3)

4.4

  

D90145

chemokine (C-C motif) ligand 3-like 1(CCL3L1)

2.6

3.0

2.0

Cytokine suppression or regulation

X52015

interleukin 1 receptor antagonist (IL1RN)

2.8

  

Adhesion molecules

NM_001078

vascular cell adhesion molecule 1 (VCAM1)

6.9

4.7

 

NM_000201

intercellular adhesion molecule 1 (CD54), human rhinovirus receptor (ICAM1)

3.5

  

NM_001816

carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)

2.0

  

NM_021219

junctional adhesion molecule 2 (JAM2)

 

2.0

2.3

NM_003370

vasodilator-stimulated phosphoprotein (VASP)

 

2.3

2.1

AF139768

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5

 

2.01

 

NM_002999

syndecan 4 (amphiglycan, ryudocan) (SDC4)

6.0

  

Other inflammation-associated genes

NM_004120

guanylate binding protein 2, interferon-inducible (GBP2)

10.2

16.3

2.3

NM_002053

guanylate binding protein 1, interferon-inducible, 67 kDa (GBP1)

3.8

4.5

 

NM_006291

tumor necrosis factor, alpha-induced protein 2 (TNFAIP2)

3.4

  

NM_006058

TNFAIP3 interacting protein 1 (TNIP1)

2.9

  

NM_006290

tumor necrosis factor, alpha-induced protein 3 (TNFAIP3)

2.5

  

NM_003821

receptor-interacting serine-threonine kinase 2 (RIPK2)

2.1

  

NM_002964

S100 calcium binding protein A8 (calgranulin A) (S100A8)

12.0

27.5

6.2

NM_002965

S100 calcium binding protein A9 (calgranulin B) (S100A9)

7.7

17.5

 

NM_007053

CD160 antigen (CD160)

 

2.2

2.0

NM_001276

chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1)

 

3.2

2.5

NM_004271

lymphocyte antigen 86 (LY86) (MD-1)

  

2.3

NM_001085

serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3)

5.6

6.8

 

NM_002818

proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (PSME2)

  

3.1

NM_004159

proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) (PSMB8)

  

3.2

Hypoxia and/or oxidative stress

NM_001530

hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A)

2.9

2.5

 

NM_003330

thioredoxin reductase 1 (TXNRD1)

2.1

  

NM_000636

superoxide dismutase 2, mitochondrial (SOD2)

12.5

 

5.0

AK055872

Haptoglobin (HP)

33.3

24.4

 

Apoptosis

AF070674

baculoviral IAP repeat-containing 3 (BIRC3)

2.9

  

NM_015675

growth arrest and DNA-damage-inducible, beta (GADD45B)

3.0

  

NM_002727

proteoglycan 1, secretory granule (PRG1)

2.3

2.4

 

NM_052889

CARD only protein (COP)

9.6

11.8

 

NM_003311

pleckstrin homology-like domain, family A, member 2 (PHLDA2)

 

3.1

 

NM_005734

homeodomain interacting protein kinase 3 (HIPK3)

  

2.0

NM_016426

G-2 and S-phase expressed 1 (GTSE1)

  

2.0

NM_005456

mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1)

  

2.3

Heat shock protein

NM_014365

heat shock 27 kDa protein 8 (HSPB8)

3.0

2.7

 

Cell proliferation tumor suppressor wound healing process

NM_003311

pleckstrin homology-like domain, family A, member 2 (PHLDA2)

  

2.8

NM_021077

neuromedin B (NMB)

  

2.0

NM_006069

murine retrovirus integration site 1 homolog (MRVI1)

  

2.7

NM_001260

cyclin-dependent kinase 8 (CDK8)

  

2.7

NM_003073

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1)

  

2.4

AK055327

fibroblast activation protein, alpha (FAP)

  

4.3

NM_005424

tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (TIE)

  

2.9

NM_002408

mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT2)

  

2.9

NM_020638

fibroblast growth factor 23 (FGF23)

  

2.3

NM_006603

stromal antigen 2 (STAG2)

  

2.3

NM_005622

SA hypertension-associated homolog (rat) (SAH)

  

2.3

AB011537

slit homolog 1 (Drosophila) (SLIT1)

  

2.2

J05158

carboxypeptidase N, polypeptide 2, 83 kD (CPN2)

  

2.1

AF339822

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1)

 

2.2

3.2

AK056352

PR domain containing 5 (PRDM5)

 

2.0

2.5

AL117643

activin A receptor, type IB (ACVR1B)

2.4

  

Coagulation

NM_001993

coagulation factor III (thromboplastin, tissue factor) (F3)

2.5

  

NM_014059

response gene to complement 32 (RGC32)

 

3.7

 

Blood pressure

NM_024409

natriuretic peptide precursor C (NPPC)

  

2.8

Energy generation

AF327403

solute carrier family 25, member 28 (SLC25A28)

2.1

  

NM_000761

cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2)

 

3.5

3.4

AL359600

ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5)

2.3

  

AF052090

nicotinamide nucleotide transhydrogenase (NNT)

  

2.7

NM_004297

guanine nucleotide binding protein (G protein), alpha 14 (GNA14)

  

2.1

Protein synthesis

AL161952

glutamate-ammonia ligase (glutamine synthase) (GLUL)

2.1

  

NM_004184

tryptophanyl-tRNA synthetase (WARS)

2.1

8.0

3.4

NM_002954

ribosomal protein S27a (RPS27A)

 

2.1

 

NM_013417

isoleucine-tRNA synthetase (IARS)

 

2.0

 

Cation transporter

NM_017964

solute carrier family 30 (zinc transporter), member 6 (SLC30A6)

  

2.0

NM_022154

solute carrier family 39 (zinc transporter), member 8 (SLC39A8)

4.4

3.6

 

D31887

solute carrier family 39 (zinc transporter), member 14 (SLC39A14)

 

2.2

 

Transcriptional regulation

NM_020529

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)

6.2

  

AK026497

YY1 transcription factor (YY1)

2.6

  

NM_004556

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon (NFKBIE)

2.4

  

NM_013448

bromodomain adjacent to zinc finger domain, 1A (BAZ1A)

2.0

  

NM_015859

general transcription factor IIA, 1, 19/37 kDa (GTF2A1)

 

2.1

 

NM_004697

PRP4 pre-mRNA processing factor 4 homolog (yeast) (PRPF4)

  

2.7

NM_005523

homeo box A11 (HOXA11)

  

2.1

NM_006540

nuclear receptor coactivator 2 (NCOA2)

  

3.5

NM_012345

nuclear fragile × mental retardation protein interacting protein 1 (NUFIP1)

  

3.4

NM_004719

splicing factor, arginine/serine-rich 2, interacting protein (SFRS2IP)

  

3.3

NM_004514

forkhead box K2 (FOXK2)

  

3.1

BG163465

I-mfa domain-containing protein (HIC)

  

2.0

AK025842

nuclear receptor subfamily 2, group F, member 2 (NR2F2)

  

2.0

Cell motility, phagocytosis, trafficking

NM_002356

myristoylated alanine-rich protein kinase C substrate (MARCKS)

3.0

  

NM_006086

tubulin, beta, 4 (TUBB4)

 

2.5

3.5

AK023457

RAP1A, member of RAS oncogene family (RAP1A)

  

2.7

Lipid

AF323540

apolipoprotein L, 1 (APOL1)

3.7

12.4

 

NM_005564

lipocalin 2 (oncogene 24p3) (LCN2)

8.6

10.7

 

NM_004190

lipase, gastric (LIPF)

  

2.1

Protein glycosylation

NM_004737

like-glycosyltransferase (LARGE)

 

2.3

 

AB067505

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)

  

2.0

NM_006042

heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (HS3ST3A1)

  

2.1

AF155510

Heparanase (HPSE)

  

2.1

NM_005424

yrosine kinase with immunoglobulin and epidermal growth factor homology domains (TIE)

  

2.9

NM_002408

mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT2)

  

2.9

NM_006577

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1)

  

3.3

Signal transduction

NM_002401

mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

  

3.0

NM_001721

BMX non-receptor tyrosine kinase (BMX)

  

2.6

NM_004297

guanine nucleotide binding protein (G protein), alpha 14 (GNA14)

  

2.1

NM_002075

guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3)

2.6

2.2

 

BC011671

guanine nucleotide binding protein (G protein), beta 5 (GNB5)

 

2.7

 

NM_004125

guanine nucleotide binding protein (G protein), gamma 10 (GNG10)

 

2.2

2.5

NM_005279

G protein-coupled receptor 1 (GPR1)

  

3.3