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Table 2 Genes downregulated by sepsis in the lung of the baboons at 2, 8 and 24 hrs post E. coli challenge

From: Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis

Gene Accession no.

Gene Product

Fold change compared to control

  

2 h

6–8 h

24 h

Cytokine, chemokine, inflammation associated gene

NM_001243

tumor necrosis factor receptor superfamily, member 8 (TNFRSF8)

 

0.23

0.18

NM_000014

alpha-2-macroglobulin (A2M)

 

0.48

 

NM_002994

chemokine (C-X-C motif) ligand 5 (CXCL5)

 

0.50

 

NM_004763

integrin beta 1 binding protein 1 (ITGB1BP1)

 

0.50

 

Immune response

NM_000587

complement component 7 (C7)

  

0.32

NM_002125

major histocompatibility complex, class II, DR beta 3 (HLA-DRB3)

  

0.33

Scaffolding protein

NM_001753

Caveolin 1 protein (CAV1)

0.49

  

Blood coagulation

NM_000361

Thrombomodulin (THBD)

0.39

0.17

0.25

NM_000611

CD59 antigen p18–20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59)

  

0.42

NM_001150

alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase) (ANPEP)

  

0.43

Collagen catabolism, extra cellular matrix

NM_004530

matrix metalloproteinase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) (MMP2)

 

0.36

0.36

AL110197

tissue inhibitor of metalloproteinase 2 (TIMP2)

 

0.46

0.45

NM_001848

collagen, type VI, alpha 1 (COL6A1)

 

0.48

 

NM_004369

collagen, type VI, alpha 3 (COL6A3)

  

0.30

NM_000362

tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) (TIMP3)

  

0.32

Cell adhesion, cell migration

NM_001901

connective tissue growth factor (CTGF)

0.37

  

AY027862

upregulated in colorectal cancer gene 1 (UCC1)

 

0.40

 

NM_001769

CD9 antigen (p24) (CD9)

 

0.30

 

NM_002026

fibronectin 1 (FN1)

 

0.37

 

AL050364

plakophilin 4 (PKP4)

 

0.44

0.43

NM_001305

claudin 4 (CLDN4)

 

0.46

 

AF022375

vascular endothelial growth factor (VEGF)

  

0.40

NM_013994

discoidin domain receptor family, member 1 (DDR1)

  

0.44

NM_014000

Vinculin (VCL)

  

0.50

Anti-inflammation

AB025432

delta sleep inducing peptide, immunoreactor (DSIPI)

0.41

 

0.39

Cell growth, proliferation, differentiation, cell cycle

NM_001946

dual specificity phosphatase 6 (DUSP6)

0.45

  

NM_002165

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1)

0.34

  

NM_006286

transcription factor Dp-2 (E2F dimerization partner 2) (TFDP2)

 

0.37

 

NM_002276

keratin 19 (KRT19)

 

0.35

 

NM_001424

epithelial membrane protein 2 (EMP2)

 

0.42

0.44

NM_001431

erythrocyte membrane protein band 4.1-like 2 (EPB41L2)

 

0.42

 

NM_005610

retinoblastoma binding protein 4 (RBBP4)

 

0.45

0.45

NM_006407

cytoskeleton related vitamin A responsive protein (JWA)

 

0.45

 

AL122055

cyclin-dependent kinase (CDC2-like) 11 (CDK11)

 

0.45

 

NM_016250

NDRG family member 2 (NDRG2)

 

0.46

 

AF368463

carboxypeptidase M (CPM)

 

0.47

0.47

NM_005708

glypican 6 (GPC6)

 

0.49

 

NM_006835

cyclin I (CCNI)

  

0.20

AB023182

serine/threonine kinase 38 like (STK38L)

 

0.32

0.11

AF218029

H3 histone, family 3B (H3.3B) (H3F3B)

  

0.22

NM_001431

erythrocyte membrane protein band 4.1-like 2 (EPB41L2)

  

0.25

NM_006185

nuclear mitotic apparatus protein 1 (NUMA1)

  

0.36

NM_001553

insulin-like growth factor binding protein 7 (IGFBP7)

  

0.37

NM_001980

Epimorphin (EPIM)

  

0.38

AK055976

thymosin, beta 4, X-linked (TMSB4X)

  

0.40

NM_005778

RNA binding motif protein 5 (RBM5)

  

0.41

NM_014399

transmembrane 4 superfamily member 13 (TM4SF13)

  

0.41

NM_006791

mortality factor 4 like 1 (MORF4L1)

  

0.47

Transcriptional regulation

NM_001271

chromodomain helicase DNA binding protein 2 (CHD2)

 

0.38

 

NM_003924

paired-like homeobox 2b (PHOX2B)

 

0.41

0.43

AJ420430

general transcription factor IIIC, polypeptide 4, 90 kDa (GTF3C4)

 

0.41

 

NM_002938

ring finger protein 4 (RNF4)

 

0.44

0.28

D49835

ras responsive element binding protein 1 (RREB1)

 

0.49

 

NM_002624

prefoldin 5 (PFDN5)

  

0.32

NM_003418

zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) (ZNF9)

  

0.34

NM_031243

heterogeneous nuclear ribonucleoprotein A2/B1 (HNRPA2B1)

  

0.36

NM_003151

signal transducer and activator of transcription 4 (STAT4)

  

0.38

AB058726

PHD finger protein 6 (PHF6)

 

0.34

0.39

NM_002228

v-jun sarcoma virus 17 oncogene homolog (avian) (JUN)

  

0.40

NM_003205

transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) (TCF12)

  

0.43

NM_031314

heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRPC)

  

0.43

NM_001300

core promoter element binding protein (COPEB)

  

0.45

AL133574

TEA domain family member 1 (SV40 transcriptional enhancer factor) (TEAD1)

  

0.45

AK027071

transforming growth factor beta-stimulated protein TSC-22 (TSC22)

  

0.46

AJ420430

general transcription factor IIIC, polypeptide 4, 90 kDa (GTF3C4)

  

0.50

Apoptosis, stress response

NM_000581

glutathione peroxidase 1 (GPX1)

  

0.30

NM_000041

apolipoprotein E (APOE)

  

0.36

NM_004394

death-associated protein (DAP)

  

0.40

NM_000851

glutathione S-transferase M5 (GSTM5)

  

0.45

NM_021003

protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A)

  

0.48

Energy generation or protein synthesis

NM_020041

solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9)

 

0.42

 

AL136693

cytochrome b reductase 1 (CYBRD1)

 

0.42

 

NM_002164

indoleamine-pyrrole 2,3 dioxygenase (INDO)

 

0.44

0.29

AF113701

ribosomal protein L22 (RPL22)

 

0.49

 

NM_021194

solute carrier family 30 (zinc transporter), member 1 (SLC30A1)

 

0.49

 

NM_000971

ribosomal protein L7 (RPL7)

  

0.22

NM_015994

ATPase, H+ transporting, lysosomal 34 kDa, V1 subunit D (ATP6V1D)

  

0.31

NM_001010

ribosomal protein S6 (RPS6)

  

0.32

NM_001867

cytochrome c oxidase subunit VIIc (COX7C)

  

0.35

NM_020041

solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9)

  

0.38

NM_001967

eukaryotic translation initiation factor 4A, isoform 2 (EIF4A2)

  

0.42

NM_001961

eukaryotic translation elongation factor 2 (EEF2)

  

0.43

NM_001418

eukaryotic translation initiation factor 4 gamma, 2 (EIF4G2)

  

0.43

NM_003753

eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67 kDa (EIF3S7)

  

0.43

NM_001460

flavin containing monooxygenase 2 (FMO2)

  

0.45

AK057575

solute carrier family 25 (mitochondrial carrier* phosphate carrier), member 3 (SLC25A3)

  

0.46

AK057299

dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (DLAT)

  

0.48

NM_016091

eukaryotic translation initiation factor 3, subunit 6 interacting protein (EIF3S6IP)

  

0.50

Cardiovascular calcifications

NM_000900

matrix Gla protein (MGP)

 

0.25

0.19

Protein transport

NM_001282

adaptor-related protein complex 2, beta 1 subunit (AP2B1)

  

0.38

NM_004914

RAB36, member RAS oncogene family (RAB36)

  

0.40

NM_002865

RAB2, member RAS oncogene family (RAB2)

  

0.34

AK057157

RAB6A, member RAS oncogene family (RAB6A)

  

0.25

AK000757

sortilin 1 (SORT1)

  

0.47