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Table 1 GO analysis results. Differentially expressed biological processes common in all cell lines after 48 h of exposure.

From: Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines

GO term* P-value/expression Genes contributing to the differential expression Total no. of genes in the GO term
Negative regulation of helicase activity < 0.01/down TP53 2
Regulation of mitochondrial membrane permeability < 0.01/down TP53 8
Positive regulation of transcription, DNA-dependent < 0.005/down ARID1A, THRAP3, GLIS1, FOXD3, ARHGEF11, ATF6, ESRRG, NCOA1, FHL2, CTNNB1, SCAP, SMARCC1, ZBTB38, TP73L, PPARGC1A, NARG1, MAML3, IL31RA, CDK7, RNF14, PPARGC1B, NSD1, MAML1, SQSTM1, NOTCH4, HMGA1, TBN /// LOC441149, TBN, TRERF1, FOXO3A, ASF1A, PLAGL1, ARID1B, CREB5, SMARCD3, GATA4, GLIS3, RXRA, NCOA4, EHF, HTATIP, RBM14, RBM14 /// MGC15912, HBXAP, CRSP6, MAML2, ATF7IP, SURB7, SP1, SMARCC2, GRIP1, TBX5, RAN /// LOC391717, NARG1L, RB1, TXNDC, MED6, TP53BP1, ELL3, PIAS1, MKL2, TGFB1I1, CTCF, MAP2K3, PPARB, BRCA1, THRAP, PIAS2, SMAD2, ILF3, MECT1, CCNE1, MLL4, DYRK1B, NCOA3, NRIP1, RUNX1, SEC14L2, ATF4, PHF5A, G22P1, CRSP2, MED12 848
Negative regulation of JNK activity < 0.01/down HIPK3 5
Prenylated protein catabolism < 0.01/down PCYOX1 4
Negative regulation of survival gene product activity < 0.01/down BNIP3L, HRK, BCL2L1, BAX 19
Ras protein signal transduction < 0.01/down PARK7, MFN2, CNKSR1, LCK, NOTCH2, IQGAP3, SOS1, LZTFL1, RASSF1, MRAS, PLD1, G3BP2, FGF2, IQGAP2, KIAA1961, RAPGEF6, G3BP, RREB1, RGL2, PLCE1, SHOC2, RASGRP2, IGF1, RASGRP1, TPM1, IQGAP1, LAT, GAS8, GRAP, KSR, NF1, GRB2, RASGRP4, RRAS, NU62, NUP62 /// IL4I1, CRKL, GRAP2 477
Cytoplasmic sequestering of NF-kappaB < 0.005/down FAF1, IL10, G3BP2, NFKBIA, BCL3 22
Regulation of MAPK activity < 0.005/down MAP3K6, SHC1, RGS4, LAX1, KIAA1804, TRIB2, SPRED2, DUSP2, MAP3K2, ZAK, PROK2, PIK3CB, ADRA2, EGF, FGF2, PRKAA1, PPP2, DUSP22, DAXX, MAPK3K5, DBNL, PP2CB, TRIB1, RGS3, PLCE1, DUSP8, HPK3, MAP3K11, PP2R1B, DUSP6, MBIP, MAP4K5, MAP3K9, SPRED1, HSPC121, GPS2, ADORA2B, GPS1, EDG5, PKN1, MAP4K1, MAP3K10, C5R1, PPP2R1, TRIB3, BIRC7, DUSP9 244
Sensory perception of smell < 0.005/up TAS1R1, TAS1R2, OR10K1, OR10, OR2C3, OR1C1, OR2W3, OR2L13, OR2M4, ADCY3, GRM7, SLIT2, YGT2A1, TAS2R1, OR2B2, ORB2B6, OR2W1, OR2B3, OR5U1, OR5V1, OR12D3, OR5V1 /// OR12D3, OR12D2, OR11A1, OR10C1, OR2H1, OR2H2, CYB5R4, TAS2R16, GRM8, TAS2R3, TAS2R4, TAS2R5, TAS2R38, OR6W1, TAS2R39, TAS2R40, TAS2R41, OR6B1, OR2S2, OR1J2, OR1J4, OR1Q1, OR51E1, OR51E2, OR52A1, OR51B4, OR51B2, OR51M1, OR51I1, OR51I2, OR52D1, OR6A2, OR10A4, OR5P2, OR5P3, PR5E1, OR10A3, OR5I1, OMP, OR8G1 /// LOC442754, OR8D1, OR8B2, OR8B8, TAS2R45, TAS2R7, TAS2R8, TAS2R9, TAS2R1, TAS2R13, TAS2R14, TAS2R50, OR4N4, OR1F1, OR1F2, OR2C1, OR1D2, OR1G1, OR1A2, OR1A1, OR3A2, OR3A1, OR1E1 /// OR1E2, OR4D1, OR4D2, OR7D2, OR7E19, OR7C1, OR7A5, OR7A10, OR7A17, OR7C2, OR1I1, OR10H2, C5R1 2589
  1. *see Additional file 1: GOanalysis for all significant GO terms at each time point.