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Table 4 Chromosome bands from the CCA results. Potential asbestos hotspots, some of which contain known asbestos-related genes. Expected false discovery rate of < 38%.

From: Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines

Region

P-value/q-value

No. of genes in the region with the most significant contribution to the common correlation*

Examples of genes

2p22

0.00260/0.3367

10

MAP4K3†, CEBPZ§,QPCT§

9p13

0.00700/0.3367

71

FANCG † , IGFBPL1 † , CCL19 † MELK †

14q21

0.00720/0.3367

22

FANCM † , CDKL1 †

5p13

0.00880/0.3367

5

 

9q21

0.00970/0.3367

29

PCSK5 †

5q13

0.01010/0.3367

9

F2RL1

8q22

0.01160/0.3367

59

CTHRC1 † , TP53INP1 † , KLF10 †

2q36

0.01260/0.3367

29

MRPL44 †

6q13

0.01300/0.3367

9

 

2q31

0.01370/0.3367

28

KIAA1715, AGPS, ITGA4 † , ITGA6 †

3q29

0.01410/0.3367

54

DLG1

3p25

0.01480/0.3367

67

COLQ†, CAMK1†, RAF1†, TMEM43,LOC51244

15q12

0.0176/0.3471

2

 

4q11

0.0178/0.3471

6

 

8p21

0.0196/0.35672

70

BNIP3L, GSR §

12q12

0.0225/0.3705

7

 

14q22

0.0258/0.3705

29

TXNDC

2q34

0.0266/0.3705

1

 

15q13

0.0272/0.3705

9

 

5q15

0.0279/0.3705

2

KIAA0372 §

3q23

0.0285/0.3705

4

 
  1. * see Additional file 5: CCA for complete lists of the genes
  2. † Known or related to a known asbestos-associated gene. ITGA4 also differentially expressed in asbestos-exposed lung cancer patients as compared to non-exposed lung cancer patients [10].
  3. § The gene also shows differential copy number in CGH array data of asbestos-exposed lung cancer patients, (data not shown, available at request)