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Table 4 Chromosome bands from the CCA results. Potential asbestos hotspots, some of which contain known asbestos-related genes. Expected false discovery rate of < 38%.

From: Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines

Region P-value/q-value No. of genes in the region with the most significant contribution to the common correlation* Examples of genes
2p22 0.00260/0.3367 10 MAP4K3, CEBPZ§,QPCT§
9p13 0.00700/0.3367 71 FANCG , IGFBPL1 , CCL19 MELK
14q21 0.00720/0.3367 22 FANCM , CDKL1
5p13 0.00880/0.3367 5  
9q21 0.00970/0.3367 29 PCSK5
5q13 0.01010/0.3367 9 F2RL1
8q22 0.01160/0.3367 59 CTHRC1 , TP53INP1 , KLF10
2q36 0.01260/0.3367 29 MRPL44
6q13 0.01300/0.3367 9  
2q31 0.01370/0.3367 28 KIAA1715, AGPS, ITGA4 , ITGA6
3q29 0.01410/0.3367 54 DLG1
3p25 0.01480/0.3367 67 COLQ, CAMK1, RAF1, TMEM43,LOC51244
15q12 0.0176/0.3471 2  
4q11 0.0178/0.3471 6  
8p21 0.0196/0.35672 70 BNIP3L, GSR §
12q12 0.0225/0.3705 7  
14q22 0.0258/0.3705 29 TXNDC
2q34 0.0266/0.3705 1  
15q13 0.0272/0.3705 9  
5q15 0.0279/0.3705 2 KIAA0372 §
3q23 0.0285/0.3705 4  
  1. * see Additional file 5: CCA for complete lists of the genes
  2. Known or related to a known asbestos-associated gene. ITGA4 also differentially expressed in asbestos-exposed lung cancer patients as compared to non-exposed lung cancer patients [10].
  3. § The gene also shows differential copy number in CGH array data of asbestos-exposed lung cancer patients, (data not shown, available at request)