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Table 1 KEGG pathway results of the genes of which the expression varied according to whether one or two functional myostatin allele(s) were present.

From: Target genes of myostatin loss-of-function in muscles of late bovine fetuses

KEGG Entity

Genes list

Percentage of annoted genes list

Focal adhesion

FN1, ITGA4, ITGA3, ARHA, COL1A1, CAPN3, CAV3, RRAS2

5.6

Axon guidance

ABLIM1, SEMA3D, ARHA, RRAS2, Limk1, NFAT5

4.2

Regulation of actin cytoskeleton

FN1, ITGA4, ITGA3, ARHA, RRAS, Limk1

4.2

Neuroactive ligand-receptor interaction

ADRA1B, GPR50, EDN2, EDNRA, THRA, GPR72

4.2

Calcium signaling pathway

ADRA1B, CAMK4, EDNRA, NFAT5, PRKACG

3.5

Cell cycle

Mcm6, HDAC4, SMC1L2, E2F1

2.8

Wnt signaling pathway

ARHA, CTBP1, NFAT5, PRKACG

2.8

Insulin signaling pathway

TSC, RRAS2, FASN, PRKACG

2.8

Glutathione metabolism

G6PD, Gclc, Gpx3, MGST1

2.8

ECM-receptor interaction

FN1, ITGA4, ITGA3, COL1A1

2.8

Cell adhesion molecules (CAMs)

ITGA4, NECL1, NCAM1

2.1

Ribosome

Rps29, RPL37A, RPL28

2.1

MAPK signaling pathway

DUSP9, RRAS2, PRKACG

2.1

T cell receptor signaling pathway

ARHA, RRAS2, NFAT5

2.1

  1. Expression data were filtered for 20% missing values, processed by ANOVA and by Genesis. A total of 189 genes were selected from 8 clusters for similar regrouping according to the homozygote or heterozygote status of the Q204X mutation. They were submitted to FatiGo+ search. Out of the 189 genes examined, 142 had a GO annotation, 42 were unknown and 5 had.... more than one ensemble ID. Amongst the 51 KEGG pathways found, only the KEGG pathway results including several genes are presented.