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Table 2 Genes up-regulated in 5-AzaC treated E. histolytica HM-1:IMSS parasites as compared to untreated controls.

From: Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression

Probe set

Baseline expression level

Fold-change

p-value

Annotation

763.m00027_s_at a

0.01

28.97

0.024

hypothetical protein

120.m00098_x_at

0.01

14.35

0.011

hypothetical protein

329.m00054_at

0.01

13.06

0.017

hypothetical protein

253.m00081_x_at

0.02

10.61

0.041

hypothetical protein

16.m00301_at

0.01

9.75

0.006

hypothetical protein

228.m00060_x_at

0.02

9.43

0.007

AIG1 family protein, putative (GO:0004765)

244.m00069_x_at

0.01

9.23

0.021

hypothetical protein

371.m00031_x_at

0.01

8.69

0.006

BspA-like leucine rich repeat protein, putative

295.m00030_at

0.02

8.11

0.036

conserved hypothetical protein

64.m00173_x_at

0.01

7.95

0.043

BspA-like leucine rich repeat protein, putative

94.m00138_at

0.02

7.09

0.033

hypothetical protein

36.m00220_s_atb

0.02

5.78

0.005

hypothetical protein

432.m00029_x_at

0.08

5.32

0.001

conserved hypothetical protein

1087.m00005_at

0.03

5.12

0.038

hypothetical protein

401.m00029_at

1.11

4.97

0.022

protein kinase, putative (GO:0005524)

92.m00177_x_at

0.05

4.39

0.009

hypothetical protein

86.m00156_s_atc

0.09

4.06

0.036

glutamine cyclotransferase, putative

287.m00045_x_at

0.03

3.93

0.026

hypothetical protein

450.m00030_at

0.12

3.90

0.043

hypothetical protein

2.m00587_x_at

0.04

3.83

0.009

hypothetical protein

115.m00143_at*

0.12

3.64

0.001

transcription initiation factor TFIID, putative (GO:0003677)

420.m00021_x_at

0.03

3.59

0.007

hypothetical protein

27.m00245_at

0.03

3.55

0.017

hypothetical protein

103.m00185_at

6.55

3.32

0.023

Fe-hydrogenase, putative (GO:0005489)

194.m00103_at*

0.07

3.27

0.029

protein kinase, putative (GO:0005524)

26.m00274_x_at

0.07

3.22

0.039

hypothetical protein

935.m00010_at

0.11

3.15

0.009

hypothetical protein

93.m00158_s_at d

0.10

3.10

0.014

DNA mismatch repair protein mutS, putative (GO:0006298)

97.m00140_at*

0.08

3.10

0.006

hypothetical protein

138.m00086_x_at

4.75

3.09

0.023

hypothetical protein

66.m00163_s_at

0.03

3.08

0.010

hypothetical protein

12.m00286_at

0.04

3.06

0.025

hypothetical protein

295.m00044_x_at

0.07

3.04

0.017

conserved hypothetical protein

141.m00082_at*

0.32

2.98

0.010

protein kinase, putative (GO:0004672)

267.m00069_at

0.04

2.96

0.001

hypothetical protein

4.m00648_x_at

0.04

2.89

0.032

hypothetical protein

112.m00119_at

0.04

2.85

0.035

hypothetical protein

472.m00058_s_ate

0.08

2.83

0.008

hypothetical protein

204.m00098_x_at

0.22

2.77

0.008

hypothetical protein

583.m00011_at

0.41

2.69

0.026

hypothetical protein

62.m00174_x_at

0.06

2.66

0.037

hypothetical protein

55.m00164_at

0.07

2.63

0.002

hypothetical protein

273.m00075_x_at

0.05

2.59

0.042

hypothetical protein

249.m00077_x_at

0.06

2.55

0.049

hypothetical protein

289.m00092_at

0.05

2.53

0.014

hypothetical protein

464.m00030_at

0.05

2.53

0.010

hypothetical protein

1.m00665_at

1.11

2.53

0.046

hypothetical protein

51.m00150_x_at

0.05

2.49

0.009

hypothetical protein

159.m00103_x_at

0.43

2.44

0.044

protein kinase, putative (GO:0004672)

19.m00288_at

0.07

2.36

0.005

hypothetical protein

308.m00054_x_at

0.05

2.34

0.009

hypothetical protein

5.m00447_x_at

0.12

2.33

0.016

hypothetical protein

51.m00167_at

0.05

2.33

0.042

hypothetical protein

27.m00266_x_at

0.06

2.30

0.050

ELL complex EAP30 subunit, putative

222.m00072_at

0.09

2.30

0.040

SPRY domain protein

183.m00091_x_at

8.10

2.30

0.026

acyl-CoA synthetase, putative (GO:0008152)

289.m00067_s_atf

0.09

2.30

0.004

short chain dehydrogenase family protein

43.m00197_x_at

7.97

2.24

0.024

cell adhesion protein (GO:0007155)

54.m00234_s_atg

1.09

2.22

0.037

hypothetical protein (GO:0005554)

4.m00613_x_at

0.12

2.21

0.007

hypothetical protein

48.m00224_s_ath

0.71

2.21

0.018

acetyltransferase, putative

75.m00156_x_at

0.11

2.17

0.007

myotubularin, putative

25.m00258_x_at

0.38

2.16

0.032

hypothetical protein

34.m00243_x_at

4.14

2.15

0.028

glucosamine 6-phosphate N-acetyltransferase, putative (GO:0008080)

314.m00052_x_at

0.07

2.12

0.041

hypothetical protein

21.m00282_at

0.21

2.08

0.038

hypothetical protein

528.m00022_at

0.10

2.03

0.018

hypothetical protein

48.m00192_at

0.17

2.01

0.013

hypothetical protein

  1. a763.m00027_s_at also represents 190.m00085 (hypothetical protein), 239.m00065 (hypothetical protein), 278.m00067 (hypothetical protein), 330.m00074 (hypothetical protein), 43.m00171 (hypothetical protein) and 458.m00061 (hypothetical protein)
  2. b36.m00220_s_at also represents 36.m00212 (hypothetical protein)
  3. c86.m00156_s_at also represents 119.m00135 (glutamine cyclotransferase, putative)
  4. d93.m00158_s_at also represents 153.m00091 (DNA mismatch repair protein mutS, putative)
  5. e472.m00058_s_at also represents 361.m00052 (hypothetical protein)
  6. f289.m00067_s_at also represents 180.m00106 (short chain dehydrogenase family protein)
  7. g54.m00234_s_at also represents 169.m00132 (hypothetical protein) and 406.m00049 (hypothetical protein)
  8. h48.m00224_s_at also represents 309.m00047 (acetyltransferase, putative)
  9. The probe set, baseline expression value in untreated E. histolytica HM-1:IMSS trophozoites, fold change in 5-AzaC treated parasites, p-value, and gene annotation are shown. Genes in bold are those for which RT-PCR confirmation was performed. Genes in italics are genes whose expression is significantly higher in E. histolytica Rahman compared to E. histolytica HM-1:IMSS (p-value 0.0002). Genes with normalized expression values >0.20 can routinely be detected by RT-PCR. Genes marked by * are those for which bisulfite sequencing was performed. For annotations, GO IDs are given where available and are provided within parentheses.
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BMC Genomics

ISSN: 1471-2164

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