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Table 5 Relative frequencies of mono- and dinucleotides in 5-AzaC modulated genes and in the whole genome.

From: Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression

 

Whole genome

Up-regulated genes

Down-regulated genes

Nucleotide

 

Coding

Promoter

Coding

Promoter

Coding

Promoter

Mononucleotide

A

0.36

0.40

0.42

0.40

0.40

0.40

 

C

0.14

0.11

0.11

0.11

0.11

0.11

 

G

0.14

0.12

0.16

0.12

0.15

0.12

 

T

0.36

0.36

0.31

0.37

0.34

0.36

Dinucleotide

AA

0.14

0.19

0.18

0.18

0.17

0.19

 

AC

0.04

0.04

0.04

0.04

0.04

0.04

 

AG

0.05

0.05

0.06

0.05

0.06

0.05

 

AT

0.12

0.12

0.12

0.13

0.13

0.12

 

CA

0.06

0.05

0.06

0.05

0.06

0.05

 

CC

0.02

0.01

0.02

0.01

0.01

0.01

 

CG

0.01

0.01

0.01

0.01

0.01

0.01

 

CT

0.05

0.04

0.03

0.04

0.04

0.04

 

GA

0.06

0.06

0.08

0.05

0.07

0.05

 

GC

0.01

0.01

0.01

0.01

0.01

0.01

 

GG

0.02

0.02

0.02

0.01

0.02

0.01

 

GT

0.04

0.04

0.04

0.04

0.04

0.04

 

TA

0.09

0.11

0.09

0.11

0.10

0.11

 

TC

0.06

0.05

0.04

0.05

0.04

0.05

 

TG

0.06

0.05

0.06

0.05

0.06

0.05

 

TT

0.14

0.15

0.11

0.16

0.13

0.16

  1. The frequency of each mono and di-nucleotide was calculated for the entire genome and for the coding and promoter regions of the genes up and down-regulated by 5-AzaC. No specific association of any given mono or di-nucleotide frequency with genes that are responsive to 5-AzaC compared to the whole genome was identified.
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BMC Genomics

ISSN: 1471-2164

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