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Table 5 Relative frequencies of mono- and dinucleotides in 5-AzaC modulated genes and in the whole genome.

From: Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression

  Whole genome Up-regulated genes Down-regulated genes
Nucleotide   Coding Promoter Coding Promoter Coding Promoter
Mononucleotide A 0.36 0.40 0.42 0.40 0.40 0.40
  C 0.14 0.11 0.11 0.11 0.11 0.11
  G 0.14 0.12 0.16 0.12 0.15 0.12
  T 0.36 0.36 0.31 0.37 0.34 0.36
Dinucleotide AA 0.14 0.19 0.18 0.18 0.17 0.19
  AC 0.04 0.04 0.04 0.04 0.04 0.04
  AG 0.05 0.05 0.06 0.05 0.06 0.05
  AT 0.12 0.12 0.12 0.13 0.13 0.12
  CA 0.06 0.05 0.06 0.05 0.06 0.05
  CC 0.02 0.01 0.02 0.01 0.01 0.01
  CG 0.01 0.01 0.01 0.01 0.01 0.01
  CT 0.05 0.04 0.03 0.04 0.04 0.04
  GA 0.06 0.06 0.08 0.05 0.07 0.05
  GC 0.01 0.01 0.01 0.01 0.01 0.01
  GG 0.02 0.02 0.02 0.01 0.02 0.01
  GT 0.04 0.04 0.04 0.04 0.04 0.04
  TA 0.09 0.11 0.09 0.11 0.10 0.11
  TC 0.06 0.05 0.04 0.05 0.04 0.05
  TG 0.06 0.05 0.06 0.05 0.06 0.05
  TT 0.14 0.15 0.11 0.16 0.13 0.16
  1. The frequency of each mono and di-nucleotide was calculated for the entire genome and for the coding and promoter regions of the genes up and down-regulated by 5-AzaC. No specific association of any given mono or di-nucleotide frequency with genes that are responsive to 5-AzaC compared to the whole genome was identified.
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