Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation

Table 1 Differentially expressed genes of MSC after high grade expansion.

Passage 2 vs passage 5 Acc.No	Gene name	log2 ratio	Fold-change
XM_016240	hypothetical protein xp_016240; loc87477//Homo sapiens similar to keratinocyte growth factor-like protein, group II – human (LOC158116)	0.92	1.89
NM_006211_1	proenkephalin; penk	1.58	2.99
NM_001854_1	collagen, type xi, alpha 1; col11a1	1.27	2.41
BC010956_1	similar to fibroblast growth factor 7 (keratinocyte growth factor)	1.03	2.04
NM_000612_1	Insulin-like growth factor 2 (somatomedin A); igf2	1.59	3.01
NM_031476_1	hypothetical protein dkfzp434b044; dkfzp434b044	1.34	2.53
U52914_1	b219ob receptor isoform hub219.3 precursor	1.13	2.19
NM_006379_1	sema domain, immunoglobulin domain (ig), short basic domain, secreted, (semaphorin) 3c; sema3c	-0.69	0.62
NM_002546_1	osteoprotegerin; tnfrsf11b	-1.03	0.49
Passage 5 vs passage 10 Acc.No
NM_019105_1	tenascin xb	0.85	1.80

List of differentially expressed genes after statistical analysis by modified version of the regularized t-test [64] (p < 0.05) for ten donors (passage 2 vs. passage 5) and five donors (passage 5 vs. passage 10).

ISSN: 1471-2164