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Table 1 A. pleuropneumoniae genes which are down-regulated during iron restriction

From: Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions

Gene ID Gene Description Fold Change
ap0497 engA putative GTP binding protein -2.27
ap0491 glnE Unknown -1.98
ap1365 srmB uncharacterized conserved protein -1.85
ap1538 traC conserved hypothetical protein -1.72
ap0677 nfnB putative nitroreductase, FMN-dependent -1.70
ap1779 mscL conserved hypothetical protein -1.69
ap0802 dxr conserved hypothetical protein, distant homolog of PhoU -1.58
ap0787 cdsA putative transcriptional regulator -1.54
ap0685 mlc protein of unknown function -1.53
ap1297+ sspA predicted iron-dependent peroxidase -1.53
ap0973 abgB possible metal dependent peptidase, unclassified -1.48
ap1405 nth possible sodium/sulphate transporter -1.41
ap1725 mviN uncharacterized membrane protein, putative virulence factor -1.38
ap0622 aroC flp operon protein C -1.28
ap0989 fstX conserved hypothetical protein -1.27
Biosynthesis of cofactors
ap0684 bioD1 probable dethiobiotin synthetase -3.49
ap1624 menA 1,4-dihydroxy-2-naphthoateoctaphenyltransferase -1.57
ap1131 hemC porphobilinogen deaminase -1.47
ap0447 hemA glutamyl-tRNA reductase -1.40
ap1080 hemN oxygen-independent corproporphyrinogen III oxydase -1.40
ap2005 menB naphthoate synthase -1.39
ap1684 ispH hydroxymethylbutenyl pyrophosphate reductase -1.37
ap2023 - 4-hydroxybenzoate synthetase -1.31
Energy Metabolism
ap0108+ nrfA nitrate reductase cytochrome c552 -10.48
ap1694+ frdA fumarate reductase flavoprotein subunit -9.20
ap1693+ frdB fumarate reductase iron-sulfur protein -7.86
ap1536 ccp cytochrome C peroxidase -6.61
ap0764+ torY nitrate/TMAO reducatse, tetraheme cytochrome C subunit -6.27
ap0996+ bisC nitrate-inducible formate dehydrogenase-N α subunit -5.68
ap0997+ bisC nitrate-inducible formate dehydrogenase-N α subunit -5.40
ap0762+ torZ trimethylamine-N-oxide reductase 2 -5.23
ap0998+ hybA formate dehydrogenase β subunit -5.23
ap0498+ ykgF putative Fe-S electron transport protein -4.78
ap1692+ frdC fumarate reductase 15 kD hydrophobic protein -4.67
ap1937 fumC fumarate hydratase class II -4.45
ap0499+ ykgE conserved putative dehydrogenase, Fe-S oxidoreductase -4.38
ap1132+ adh2 alcool dehydrogenase 2 dehydrogenase -3.36
ap1163+ pflB formate acetyltransferase -3.01
ap1221 aspA aspartate ammonia-lyase -2.78
ap1848+ dmsA dimethyl sulfoxyde reductase -2.73
ap1222 aspA aspartate ammonia-lyase -2.69
ap0110+ nrfC nitrate reductase, Fe-S protein -2.63
ap0380 glgB 1,4-α-glucan branching enzyme -2.55
ap0414 glpK putative glycerol kinase -2.29
ap0109+ nrfB nitrate reductase, cytochrome C-type protein -2.25
ap1255 pfkA Phosphofructokinase -2.20
ap1486+ hyaA Ni-Fe hydrogenase I small subunit -2.09
ap1525+ ccmF cytochrome C-type biogenesis protein -1.98
ap1181+ nfrE cytochrome c-type biogenesis protein -1.88
ap0418+ glpA anaerobic glycerol-3-phosphate dehydrogenase, subunit A -1.76
ap0958+ sdaA L-serine dehydratase -1.75
ap0420+ glpC anaerobic glycerol-3-phosphate dehydrogenase, subunit C -1.72
ap1979 torA trimethylamine oxydoreductase precursor -1.70
ap1528+ ccmC cytochrome C-type biogenesis protein -1.69
ap1000+ fdhE formate dehydrogenase formation protein -1.62
ap0328+ cydB cytochrome D ubiquinol oxidase subunit II -1.61
ap1588+ napF ferredoxin-type protein -1.55
ap1402 pgk phosphoglycerate kinase -1.55
ap1585+ torC nitrate/TMAO reductase, tetraheme cytochrome C subunit -1.53
ap0089 dAK1 dihydroxyacetone kinase -1.51
ap0541 maeA malate oxydoreductase -1.46
ap0326+ cydA cytochrome D ubiquinol oxidase subunit I -1.45
ap0484 gapA glyceraldehydes-3-phosphate dehydrogenase -1.35
ap1822 atpH ATP synthase δ chain -1.28
ap1116 galK Galactokinase -1.26
Transport and binding proteins: cations and iron
ap0169+ aopA NADH-ubiquinone oxidoreductase, Na+-translocating A subunit (nqrA) -2.38
ap0354 nhaB Na+/H+ antiporter protein -2.14
ap0170+ nqrB NADH degydrogenase, Na+-translocating B subunit -2.09
ap0172+ nqrD NADH-ubiquinone oxidoreductase, Na+-translocating D subunit -2.05
ap0171+ nqrC NADH-ubiquinone oxidoreductase, Na+-translocating C subunit -2.02
ap1972 nadR putative periplasmic binding protein, ABC metal ion uptake -1.61
ap0173+ nqrE NADH-ubiquinone oxidoreductase, Na+-translocating E subunit -1.52
Transport and binding proteins: others
ap1470 dcuB2 anaerobic C4-dicarboxylate membrane transporter -5.81
ap0416 glpT glycerol-3-phosphate transporter -3.71
ap1835 manX PTS system enzyme IIAB, mannose specific -2.28
ap1548 mMT1 PTS system mannose-specific EII AB component -1.83
ap1473 ptsB PTS system, sucrose-specific IIBC component, -1.67
ap1477 ptsH PTS system phosphocarrier protein HPr -1.65
ap1620 glpF glycerol uptake facilitator -1.56
ap1164 focA probable formate transporter -1.54
ap0924 cydC ABC transporter involved in cytochrome bd biosynthesis -1.51
ap1833 hisS PTS system component IID, mannose specific -1.48
ap1580 rbsB galactose ABC transporter, periplasmic binding protein -1.48
ap0886 sapC peptide transport system permease protein -1.39
ap1698 dcuB1 anaerobic C4-dicarboxylate transporter -1.38
ap2065 mscS small-conductance mechanosensitive channel -1.37
ap1367 PM0514 permease of unknown function -1.34
ap1478 ptsI phosphoenolpuruvate PTS system enzyme I -1.32
ap1463 proP permease of the major facilitator superfamily -1.32
ap1507 artQ arginine transport system permease protein -1.22
Purines, pyrimidines, nucleosides and nucleotides
ap2022 udp uridine phosphorylase -2.21
ap1237 purT phorphoribosyglycinamide formyltransferase 2 -1.67
ap0154 pyrG CTP synthase -1.54
ap1922 cdpC 2',3'-cyclic-nucleotide 2'-phosphodiesterase -1.46
ap0862 pyrD dihydroorotate dehydrogenase -1.42
ap1204 purA adenylosuccinate synthetase -1.37
ap0863 prsA ribose-phosphate pyrophosphokinase -1.34
ap0729 purE phosphoribosylaminoimidazole carboxylase catalytic subunit -1.33
Regulatory functions
ap1392 ansB probable carbon starvation protein A, membrane bound -2.59
ap1803 glpR transcriptional regulator of sugars metabolism -1.51
ap1048 baeS sensory transduction histidine kinase -1.36
Protein fate
ap1485+ hypF Ni-Fe hydrogenase maturation protein -2.39
ap2081 lgt prolipoprotein diacylglyceryl transferase -1.58
ap0428 pepB peptidase B -1.38
Protein synthesis
ap0241 thrS threonyl-tRNA synthetase -1.40
Cellular processes
ap0725 uspA universal stress protein A -1.59
ap0333 tolB colicin tolerance protein -1.29
Cell envelope
ap1215 ompW outer membrane protein W -10.00
ap1156 rplK COG5039: exopolysaccharide biosynthesis protein -1.32
ap0021 HI1139 UDP-N-acetylmuramate-alanine ligase (murC) -1.23
ap1154 ushA glycosyltransferase involved in LPS biosynthesis -1.19
Fatty acids and phospholipids metabolism
ap2049 accC biotin carboxylase -1.24
Amino acids biosynthesis    
ap0351 OB1054 putative methionine synthase -1.55
DNA metabolism
ap1336 - putative hsdR, type 1 site-specific restriction-modification system, R subunit -1.54
ap0703 alxA-hsdM type I restriction-modification system methylation subunit -1.41
ap1247 recQ ATP-dependent DNA helicase -1.21
Central intermediary metabolism
ap1787 ureC urease α subunit -1.45
ap1785 ureE metallochaperone for urease -1.22
  1. + Genes coding for iron-containing proteins or proteins using Fe2+ as a cofactor.