Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions

Deslandes, Vincent; Nash, John HE; Harel, Josée; Coulton, James W; Jacques, Mario

doi:10.1186/1471-2164-8-72

BMC Genomics

Table 2 A. pleuropneumoniae genes which are up-regulated during iron restriction

From: Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions

Gene ID	Gene	Description	Fold Change
Hypothetical/Unclassified/Unknown
ap2147⁺	-	possible N-methylhydantoinase B/acetone carboxylase, α subunit	6.22
ap0740	-	predicted iron-dependent peroxidase	3.56
ap2196	PM1515	protein of unknown function	3.40
ap0741⁺	-	predicted high-affinity Fe²⁺/Pb²⁺ permease	3.06
ap2146	-	possible N-methylhydantoinase B/acetone carboxylase, α subunit	2.88
ap0739⁺	ccrA1	predicted periplasmic protein involved in iron transport	2.69
ap2014	rpmJ1	conserved hypothetical protein	2.01
ap0286	nagB	conserved hypothetical protein	1.85
ap1686	araJ	conserved hypothetical protein	1.84
ap2182	rpsU	conserved hypothetical protein	1.83
ap2207	PM1452	protein of unknown function	1.63
ap0035	-	hypothetical protein	1.62
ap1927	-	outer membrane lipoprotein A	1.59
ap1436	NMA1782	conserved hypothetical protein	1.57
ap0755	aroA	conserved hypothetical protein	1.55
ap0874	-	hypothetical protein	1.54
ap0143	rplI	HIT-like protein	1.51
ap0056	typA	predicted membrane GTPase involved in stress response	1.51
ap1364	add	conserved hypothetical protein	1.49
ap1252	icc	conserved putative lipoprotein	1.45
ap0371	yrbK	conserved hypothetical protein	1.43
ap0478	HI0719	conserved hypothetical protein	1.43
ap1444	fimD	conserved hypothetical protein	1.43
ap1598	slyD	hypothetical protein	1.41
ap0907	HI1265	conserved hypothetical protein	1.41
ap0375	firA	conserved hypothetical protein	1.39
ap0079	comF	conserved glutaredoxin-like protein	1.37
ap0329	mlc	conserved hypothetical protein	1.36
ap1664	HI1720	conserved hypothetical protein	1.34
ap0059	dnaQ	uncharacterized stress-induced protein	1.30
ap1172	PM1281	predicted permease	1.30
ap0324	ureF	conserved hypothetical protein	1.16
Biosynthesis of cofactors
ap0423	ribB	riboflavin synthase α subunit	1.59
ap0422	ribG	riboflavin-specific deaminase	1.43
ap0947	licA	putative oxygen-independent coproporphyrinogen III oxidase (HemN)	1.37
ap1036	fdx2	ferredoxin	1.35
Energy metabolism
ap2032	lldD	l-lactate dehydrogenase	4.98
ap1733	xylB	probable L-xylulose kinase (L-xylulokinase)	3.04
ap1424	ndh	NADH dehydrogenase	1.86
ap1363	fldA	flavodoxin	1.61
Transport and binding proteins: cations and iron
ap1740⁺	tonB1	energy transducing protein	8.71
ap2142⁺	PM0741	outer membrane protein, Fe transport, hemoglobin	6.15
ap1175⁺	hgbA	hemoglobin-binding protein precursor	5.89
ap1176⁺	hgbA	hemoglobin-binding protein precursor	5.45
ap2144⁺	NMB1668	hemoglobin receptor	4.78
ap1177⁺	hugZ	heme utilization protein	4.14
ap0295⁺	yfeA	iron (chelated) ABC transporter, periplasmic-binding protein	3.88
ap2143⁺	PM0741	outer membrane protein, Fe transport, haemoglobin	3.66
ap0296⁺	yfeA	iron (chelated) ABC transporter, periplasmic-binding protein	3.55
ap1453⁺	omp64	outer membrane protein, TonB dependent receptor	3.09
ap0294⁺	yfeB	iron (chelated) transporter, ATP-binding protein	2.98
ap2145⁺	NMB1668	hemoglobin receptor	2.85
ap0300⁺	omp64	outer membrane protein, TonB dependent receptor	2.07
ap0301⁺	omp64	outer membrane protein, TonB dependent receptor	1.93
ap0797⁺	fetB2	putative ferric enterobactin transporter binding protein	1.76
ap0796⁺	fetB2	putative ferric enterobactin transporter binding protein	1.60
ap0082⁺	tonB2	energy transducing protein	1.57
ap0801⁺	NMB1993	iron(III) ABC transporter, ATP-binding protein	1.49
ap0144⁺	yfeD	iron (chelated) transport system, membrane protein	1.47
ap0145⁺	yfeC	iron (chelated) transport system, membrane protein	1.38
Transport and binding proteins: others
ap1437	NMA0994	putative periplasmic protein	1.58
Regulatory functions
ap0726	hlyX	FNR-like transcriptional regulator	2.63
ap0652	HI0893	transcriptionnal repressor Bm3R1	1.24
Protein fate
ap0399	ssa1	subtilisin-like serine protease	2.36
ap0400	ssa1	subtilisin-like serine protease	2.22
ap0401	ssa1	subtilisin-like serine protease	2.01
ap1887	def	peptide deformylase	1.64
ap1432	clpP	ATP-dependent Clp protease	1.54
ap1160	prlC	oligopeptidase A	1.39
ap1134	mopB	heat-shock 10 protein GroES	1.36
ap1431	clpX	ATP-dependent Clp protease, ATP-binding ClpX subunit	1.20
Protein synthesis
ap0337	tdk	probable tRNA-dihydrouridine synthase C	1.95
ap1295	potD1	probable pseudo-uridine synthase	1.35
ap1895	rplK	50S ribosomal protein L11	1.32
ap1305	rplI	50S ribosomal protein L9	1.31
ap1253	rluD	pseudo-uridine synthase	1.24
ap0245	infC	translation initiation factor IF-3	1.23
ap1666	valS	valyl-tRNA synthetase	1.22
Cellular processes
ap0168	napC	transformation locus protein OrfG	1.62
ap1505	HI1275	tellurite resistance protein TehB	1.61
ap1606	apxIC	RTX-1 toxin determinant	1.57
ap0688	ftsK	cell division protein FtsK	1.27
ap0025	ftsA	cell division protein FtsA	1.22
Cell envelope
ap0486	mreB	similar to rod shape-determining protein MreB	1.33
ap0507	lapB	putative membrane protein, virK family member	1.30
Fatty acids and phospholipids metabolism
ap1649	accA	acetyl-CoA carboxylase carboxyl transferase α subunit	1.38
Amino acids biosynthesis
ap2037	ilvC	ketol-acid reductoisomerase	2.38
ap1566	gshA	putative gluthatione biosynthesis bifunctionnal protein	1.51
ap0466	argG	argininosuccinate synthetase	1.24
DNA metabolism
ap2148	mutL	DNA mismatch repair protein MutL	1.34
ap2202	srmB	ATP-dependent RNA helicase	1.19
Central intermediary metabolism
ap1688	HI0111	gluthatione transferase	1.24

⁺ Genes coding for proteins involved in iron transport

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ISSN: 1471-2164

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