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Table 2 Univariate and multivariate analysis in the prognostic subset of 89 primary tumors

From: Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

   

Metastasis-free survival

Factors

Total Number

Metastasis-free/Metastasis developed

Univariate analysis

Multivariate analysis

   

HR (95% CI)

P -value

HR (95% CI)

P -value

Number of samples

89

50/39

    

Tumor size

      

   Median (range) cm

9 (2 – 30)

7.5 (2 – 28)/10 (3 – 30)

1.1 (1.02 – 1.12)

0.012

1.2 (1.01–1.14)

0.021

Necrosis

      

   Absent

23

18/5

1.0

   

   Present

66

32/34

2.9 (1.12 – 7.50)

0.028

1.6 (0.55–4.52)

0.402

Vascular invasion a

      

   Absent

72

43/29

1.0

   

   Present

17

7/10

2.4 (1.11 – 5.17)

0.026

2.2 (0.98–5.00)

0.055

Cross-validated classifier a

      

   low-risk group

46

32/14

1.0

   

   high-risk group

43

18/25

2.4 (1.20 – 4.73)

0.013

2.2 (1.04–4.62)

0.04

  1. aProportional hazards assumptions assume constant mortailty ratios and are therefore not met. Thus, the estimated HRs should be interpreted as averages over time. The effects are considerably larger initially and level off with time.