|  |  | Metastasis-free survival | |||
---|---|---|---|---|---|---|
Factors | Total Number | Metastasis-free/Metastasis developed | Univariate analysis | Multivariate analysis | ||
 |  |  | HR (95% CI) | P -value | HR (95% CI) | P -value |
Number of samples | 89 | 50/39 | Â | Â | Â | Â |
Tumor size | Â | Â | Â | Â | Â | Â |
   Median (range) cm | 9 (2 – 30) | 7.5 (2 – 28)/10 (3 – 30) | 1.1 (1.02 – 1.12) | 0.012 | 1.2 (1.01–1.14) | 0.021 |
Necrosis | Â | Â | Â | Â | Â | Â |
   Absent | 23 | 18/5 | 1.0 |  |  |  |
   Present | 66 | 32/34 | 2.9 (1.12 – 7.50) | 0.028 | 1.6 (0.55–4.52) | 0.402 |
Vascular invasion a | Â | Â | Â | Â | Â | Â |
   Absent | 72 | 43/29 | 1.0 |  |  |  |
   Present | 17 | 7/10 | 2.4 (1.11 – 5.17) | 0.026 | 2.2 (0.98–5.00) | 0.055 |
Cross-validated classifier a | Â | Â | Â | Â | Â | Â |
   low-risk group | 46 | 32/14 | 1.0 |  |  |  |
   high-risk group | 43 | 18/25 | 2.4 (1.20 – 4.73) | 0.013 | 2.2 (1.04–4.62) | 0.04 |