Skip to main content

Table 2 Univariate and multivariate analysis in the prognostic subset of 89 primary tumors

From: Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

    Metastasis-free survival
Factors Total Number Metastasis-free/Metastasis developed Univariate analysis Multivariate analysis
    HR (95% CI) P -value HR (95% CI) P -value
Number of samples 89 50/39     
Tumor size       
   Median (range) cm 9 (2 – 30) 7.5 (2 – 28)/10 (3 – 30) 1.1 (1.02 – 1.12) 0.012 1.2 (1.01–1.14) 0.021
Necrosis       
   Absent 23 18/5 1.0    
   Present 66 32/34 2.9 (1.12 – 7.50) 0.028 1.6 (0.55–4.52) 0.402
Vascular invasion a       
   Absent 72 43/29 1.0    
   Present 17 7/10 2.4 (1.11 – 5.17) 0.026 2.2 (0.98–5.00) 0.055
Cross-validated classifier a       
   low-risk group 46 32/14 1.0    
   high-risk group 43 18/25 2.4 (1.20 – 4.73) 0.013 2.2 (1.04–4.62) 0.04
  1. aProportional hazards assumptions assume constant mortailty ratios and are therefore not met. Thus, the estimated HRs should be interpreted as averages over time. The effects are considerably larger initially and level off with time.