| | |
Metastasis-free survival
|
---|
Factors
|
Total Number
|
Metastasis-free/Metastasis developed
|
Univariate analysis
|
Multivariate analysis
|
---|
| | |
HR (95% CI)
|
P -value
|
HR (95% CI)
|
P -value
|
---|
Number of samples
|
89
|
50/39
| | | | |
Tumor size
| | | | | | |
Median (range) cm
|
9 (2 – 30)
|
7.5 (2 – 28)/10 (3 – 30)
|
1.1 (1.02 – 1.12)
|
0.012
|
1.2 (1.01–1.14)
|
0.021
|
Necrosis
| | | | | | |
Absent
|
23
|
18/5
|
1.0
| | | |
Present
|
66
|
32/34
|
2.9 (1.12 – 7.50)
|
0.028
|
1.6 (0.55–4.52)
|
0.402
|
Vascular invasion
a
| | | | | | |
Absent
|
72
|
43/29
|
1.0
| | | |
Present
|
17
|
7/10
|
2.4 (1.11 – 5.17)
|
0.026
|
2.2 (0.98–5.00)
|
0.055
|
Cross-validated classifier
a
| | | | | | |
low-risk group
|
46
|
32/14
|
1.0
| | | |
high-risk group
|
43
|
18/25
|
2.4 (1.20 – 4.73)
|
0.013
|
2.2 (1.04–4.62)
|
0.04
|
- aProportional hazards assumptions assume constant mortailty ratios and are therefore not met. Thus, the estimated HRs should be interpreted as averages over time. The effects are considerably larger initially and level off with time.