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Figure 7 | BMC Genomics

Figure 7

From: Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse

Figure 7

Diagram for the genomic region encompassing the loci of SAMD9 and SAMD9L in human, mouse and rat along with the segmental duplications. Exons are shown as a red box. Segmental duplications are shown as orange, green, blue and grey boxes. Two orange segmental duplications may mediate chromosomal breakage with subsequent deletion of SAMD9, and the centromeres of chromosome 6 and 5 are formed at the sites of breakage. The grey segmental duplications, sharing the sequence among numerous centromeric loci, are accumulated at the centromere of chromosome 5. The green and blue segmental duplications flanking the SAMD9L are mouse specific based on sequence similarity, while the orange and grey segments have occurred at about the same time as the divergence of mouse and rat.

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