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Table 1 Pairwise sequence comparison of the coding and the 5'-flanking sequence of mammalian HL genes.

From: Comparative genomics and experimental promoter analysis reveal functional liver-specific elements in mammalian hepatic lipase genes

 

upstream regulatory sequence

 

cDNA sequence

81

 

53

53

61

57

56

hedgehoga

 

79

76

 

86

64

55

59

mouse

 

79

76

92

 

63

57

57

rat

 

85

82

79

79

 

94

94

rhesusa

 

85

82

80

80

96

 

98

chimp

 

85

82

79

79

96

99

 

human

 

rabbitb

hedgehog

mouse

rat

rhesus

chimp

human

 
  1. Sequence identity (%) was determined by pairwise alignment using the DNAMAN software package (optimal alignment; gap open penalty 10.0, gap extension penalty 5.0). cDNA sequence was from the translation start ATG up till the stopcodon; the upstream regulatory region was from -1400 up till the translation start ATG.
  2. a: Because of a gap in upstream regulatory region of the public sequence of the rhesus monkey and hedgehog HL gene (Ensembl e ! 42: Dec 2006), alignments with the rhesus and hedgehog sequence were done with the sequence from -900 and -1000 up till the start ATG, respectively.
  3. b:the rabbit HL cDNA sequence was taken from [38].