B. subtilis and T. maritima hexanucleotide ZOM and tetranucleotide MCM autocorrelation profiles. Hexanucleotide ZOM (red) and tetranucleotide MCM (blue) based autocorrelation profiles. Autocorrelation scores (vertical axis) were obtained with 5 kbp and 20 kbp sliding windows, overlapping every 2.5 kbp and 5 kbp, respectively, and correlated with mean genomic values. The horizontal axis represents genome position and each point of the red and blue curves spans 5 kbp, while each point of the light blue and pink curves spans 20 kbp. It can be observed from the graphs that increasing sliding window size increases average autocorrelation score for both hexanucleotide ZOM and tetranucleotide MCM profiles, but reduces detail. The tetranucleotide MCM measure (blue and light blue curves) had, in general, larger variance for the genomes tested than the hexanucleotide ZOM measure (red and pink curves), implying that the MCM measure was more sensitive to genomic changes.