Figure 5

Homology search/alignment based on heptanucleotide ROFs in Mycobacterium leprae. Homology search based on heptanucleotide ROFs in M. leprae, using a 1 kbp non-overlapping sliding window compared with a vector consisting of heptanucleotide frequencies taken from 5 kbp of T. maritima DNA consisting of 16S, 23S and 5S rRNA genes. The horizontal axis represents nucleotide positions, each point spanning 1 kbp, in the M. leprae chromosome, while the vertical axis gives correlation values based on comparisons between the sliding window and the T. maritima DNA vector. The marked peak indicates the closest hit, containing corresponding rRNA genes in M. leprae. Although M. leprae is very distantly related to T. maritima (hexanucleotide ZOM score of 0.13) its rRNA genes could be detected using DNA from the corresponding T. maritima rRNA genes with the search method based on ROFs.