Skip to main content

Table 1 Summary of the highest represented functional groups of genes from the PRG list. Up-regulated genes are in bold type, down-regulated genes in italics.

From: Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes

Top Biological Functions

Genes

Lipid Metabolism

PRDX6, HEXB, APOD, OSBP, BMPR1B, PTPMT1, LTC4S, DHCR24, APOE, SGPP1, PITPNC1, HMGCS2, OSBPL1A, GRN, CYP46A1, ABCA1

Nervous system function and synaptic transmission

MBP, PMP22, PLP1, CBLN1, APOE, CHRNB4, YWHAG, CART, MAL, VAMP1, VAMP2, SYT2, SYN2, SNPH, RPH3A, CAMK2A, SEPT, CTNNB1, DNER, THY1, CD9, RTN4, NRXN1, NRXN2, PTN

Cytoskeleton organization and biogenesis

SGCB, APOE, TMSB4X, THY1, CAPZB, RHOF, LASP1, CNN3, ARPC3, YWHAG, TLN1, TUBB2A, ERBB2IP, DCTN2, MYL6, GFAP, MAP1LC3B, ALS2CR2, NEFL, MYH11, EPB49

Protein biosynthesis and folding

RPL11, RPS3, RPS27, FAU, RPS9, WBSCR1, SECISBP2, RPL9, EEF1A1, RPL24, RPL26, CCT6A, ERP29, HSPB3, PPIL2, CRYAB, DNAJA1, WBSCR18, HSPA9B, HSP90AB1

Lysosome, organization and biogenesis

LAPTM5, CTSS, PRDX6, MCOLN1, PPT1, CTSB, LAMP2, HEXB, CTSK, CTSH

Proteolysis

UCHL5, SNX17, PSMA3, CTSS, SHFM1, ASRGL1, CTSB, PGCP, CTSK, CTSH, MMP14

Apoptosis

APOE, CTSB, LY86, SGK, HIPK2, MAL, NFKB1A, PPM1F, APLP1, TRAF5, CLU, CTNNB1, PRKCE, TIMM50, ALS2CR2, SOX9, DDIT3, TM2D1, SGPP1, THY1, TNF, SPP1, YWHAG, RTN4, TGFB1, HSPA9B

Immune cell activation and inflammatory response

EGR1, THY1, TGFB1, SPP1, IGBP1, PRKCD, CBLB, LY86