Table 3 Variable amino acid sites located in COXI/II/III. These sites located on the mtDNA encoded subunits of COX (subunits I, II and III) show significant amino acid properties variation and are in contact with the nuclear encoded subunits of Complex IV (subunits IV, VB, VIA, VIB, VIIA, VIIB, VIIC and VIII).

IV

483

VB

510

155, 230

VIA

38, 122, 155, 182, 185, 230

VIB

92

VIIA

4

41

VIIB

406

VIIC

4, 502

VIII

406, 483