Figure 1
From: Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility
Genetic association scan for germline c-MYC differential expression in CEUs and YRIs. (A) Top panel shows results for individual SNPs and bottom panel shows results for significant SNP density in genomic windows of ~42 kb/~66 SNPs in CEUs. The red horizontal dashed line marks the nominal P value of 0.05. Variants associated with risk of breast [9], colorectal [10-13] or prostate [1-8, 24] cancer are marked with dashed lines as indicated in the inset. (B) Top panel shows results for individual SNPs and bottom panel shows results for significant SNP density in genomic windows of ~36 kb/~61 SNPs in YRIs. Linkage disequilibrium (D'/LOD) plots are shown at the bottom for YRIs. Region 1 of prostate cancer risk is shown.