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Table 1 Bi-codon frequencies. The third column lists those codons c for the first amino acid (AA1) in a consecutive pair which lead to a stop in frame -1. The overall relative frequency of c as a codon for AA1 is given in the fifth column. The relative frequency of c in the specific context AA1-AA2 is given in column six. The penultimate column shows the enrichment of the codon c in this context; an enrichment > 1 indicates that this codon is more frequently used for AA1 when it leads to a stop in frame -1 than in the average case. Probability (P) values were assigned using the χ2 test, and significance determined with a Bonferroni multiple testing correction (15 analyses). Single (*) and triple (***) asterisks indicate significance at the 0.05 and 0.001 levels, respectively.

From: Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts

AA1 AA2 First codon leading to stop in frame -1 Overall frequency Frequency when leading to stop Enrichment P
A D GCT 27 38 1.4 0.034
C D TGT 45 80 1.8 1.814e-07 ***
D D GAT 46 78 1.7 2.38e-06 ***
F D TTT 46 80 1.7 5.358e-07 ***
G D GGT 16 23 1.4 0.08
H D CAT 42 69 1.6 3.097e-05 ***
I D ATT 36 55 1.5 0.002 *
L D CTT 13 12 0.9 0.782
N D AAT 47 78 1.7 6.131e-06 ***
P D CCT 29 36 1.2 0.194
R D CGT 8 9 1.1 0.724
S D TCT, AGT 34 51 1.5 0.004 *
T D ACT 25 31 1.2 0.230
V D GTT 18 19 1.1 0.814
Y D TAT 44 75 1.7 2.962e-06 ***
W D - - - -  
Q D - - - -  
M D - - - -  
K D - - - -  
E D - - - -