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Table 2 Viral probes and fold-change during infection kinetics.

From: Transcriptomic analysis of the dialogue between Pseudorabies virus and porcine epithelial cells during infection

Amplicon name Transcript name Fold-change Encoded protein and function* Structural role*
   T0 T1 T2 T4 T8 T12   
ORF1 ORF1 - - - - -   unknown virion
UL54 UL52/UL53/UL54 - - - - - -   
UL53 UL52/UL53 - - 4.6 6.6 6.7 7.4   
UL52 UL52 - - - 4.7 6.4 5.6 DNA replication; primase subunit of UL5/UL8/UL52complex nonstructural
UL51 UL51 - - - - - - viral egress tegument
UL50 UL50 - - - - - - dUTPase nonstructural
UL49.5 UL49.5 - 4.4 6.4 9.0 10.4 13.5 gN; immune evasion (TAP inhibitor) envelope
UL49 UL49.5/UL49 - - - - - -   
UL48 UL48 - - - - - - VP16, α-TIF; gene regulation(transactivator); viral egress tegument
UL47 UL48/UL47 - - - - 4.0 3.9   
UL46 UL48/UL47/UL46 - - - - - - VP11/12; unknown; tegument protein  
GII UL28/UL27 - - - - 6.7 6.3   
ICP18.5 UL28 - - - - - 7.4 ICP18,5; DNA cleavage and packaging; component of the UL15/UL28 terminase capsid precursor
UL29 UL29 - 6.0 9.2 10.6 8.9 10.9 ICP8; DNA replication and recombination; binds ssDNA nonstructural
UL30 UL30 - - 4.2 - - - DNA replication; DNA polymerase subunit of UL30/UL42 holoenzyme nonstructural
UL31 UL32/UL31 - - - 4.5 9.2 10.1   
UL32 UL32 - - - - 4.0 4.1 DNA packaging; efficient localization of capsids to replication compartments capsid precursor
UL33 UL33 - - - - 4.5 5.8 DNA cleavage and packaging; associates with UL28 and UL15 nonstructural
UL34 UL33/UL34 - - - - 6.1 5.0   
UL35 UL33/UL34/UL35 - - 5.6 7.1 9.5 9.5   
UL361 UL36 - - - - - - VP1/2; viral egress(capsid tegumentation); interacts with Ul37 and capsid tegument
UL362 UL36 - - - - - 3.8 VP1/2; viral egress(capsid tegumentation); interacts with Ul37 and capsid tegument
UL37 UL37maj/UL37min - - - - - 5.0   
UL38 UL38 - - - - - - VP19c; minor capsid protein; UL38/UL18/UL18 triplex component capsid
UL39 UL39 - - - - 4.4 6.3 nucleotide synthesis; large subunit of ribonucleotide reductase nonstructural
UL40 UL39/UL40 - - - - - -   
UL41 UL41 - - - - 4.2 6.8 VHS, gene regulation; Rnase, degrades host and viral mRNAs tegument
UL42 UL42 - - - 6.3 6.9 4.6 DNA replication; polymerase accessory subunit of UL30/UL42 holoenzyme nonstructural
UL43 UL43 - - - - 4.1 6.2 inhibits glycoprotein-mediated membrane fusion; type III membrane protein envelope
GIIINIA3 UL44 - - - 8.2 12.7 13.9 gC; viral entry (virion attachment); type I membrane protein envelope
ORF2NIA3 UL24/UL25/UL26/UL26.5 - - - - - -   
UL26NIA3 UL24/UL25/UL26 - - - 6.7 8.3 7.6   
ORF1NIA3 UL24/UL25      8.1 8.0   
UL25NIA3 UL24/UL25 - - - 8.3 10.7 12.2   
UL24NIA3 UL24 - - - 6.9 9.8 10.4 unknown, type III membrane protein unknown
TKNIA3 UL23 - - - - 5.0 6.8 TK, nucleotide synthesis; thymidine kinase; selectively activates acyclovir nonstructural
GHNIA3 UL22 - - 4.8 6.0 8.8 9.0 gH; viral entry (fusion); cell-cell spread; type i membrane PT envelope
UL21NIA3 UL21 - - - - 5.9 5.5 unknown; capsid-associated tegument protein; interacts with UL16 tegument
UL20NIA3 UL20 - - - 3.8 5.3 7.3 viral egress, type III membrane protein unknown
UL191 UL19maj/UL19min - - - 5.0 9.7 10.8   
UL192 UL19maj/UL19min - - 6.6 8.6 12.6 12.9   
UL18 Ul19min/UL18 - - - 7.0 5.7 9.6   
UL15EX2 UL15 (2nd exon) - - 6.4 6.5 7.5 9.2 DNA cleavage/encapsidation; terminase subunit of UL15/UL28 terminase6 capsid precursor
UL17 UL17 - - - - - - DNA cleavage and encapsidation inner capsid
UL16 UL17/Ul16 - - - 4.5 6.2 5.0   
UL15EX12 UL15 (1st exon) - - - - 4.0 7.7 DNA cleavage/encapsidation; terminase subunit of UL15/UL28 terminaseUL6 capsid precursor
UL14 UL14     6.1 6.1 9.8 unknown unknown
UL142 UL14 - - - - 6.3 7.8 unknown unknown
UL13 UL14/UL13 - - - - - -   
UL12 UL14/UL13/UL12 - - - - 3.7 5.3   
UL11 UL14/UL13/UL12/UL11 - - - - - 6.0   
UL10 UL10 - - - - 6.6 6.1 gM; inhibits glycoprotein-mediated membrane fusion; type III membrane protein envelope
UL92 UL9 - - - - - 4.1 not found non structural
UL8.5 UL9/UL8.5 - - - 4.0 - -   
UL8 UL9/UL8.5/UL8 - - - - - -   
UL7 UL6/UL7 - - 5.0 7.4 10.7 9.4   
UL6 UL6 - - 5.0 12.7 13.8 13.3 capsid protein; portal protein; docking site for terminase capsid
UL5 UL5 - - 4.3 6.3 8.7 5.9 DNA replication; part of UL5/UL8/UL52 helicase/primase complex nonstructural
UL4 UL5/UL4 - - - - 3.5 5.5 unknown  
UL3.5 UL1/UL2/UL3/UL3.5 - - - - - -   
UL3 UL1/UL2/UL3 - - - - 5.1 6.5   
UL2 UL1/UL2 - - - 4.2 5.4 5.4   
UL1 UL1 - - - - 6.5 7.3 gL; viral entry (fusion); sell-sell spread envelope
LLTE1 LLT (1st exon) - - - 4.6 6.5 8.0 not found unknown
EP02 EP0/LLT - - - - - -   
EP01 EP0/LLT - - - - 6.3 4.7   
LLTI2 LLT intron - - - - 3.7 4.7   
LLTE21 LLT (2nd exon) - - - - - - not found unknown
IEP2 IE180 - - - 3.5 - - ICP4; gene regulation (transactivator); immediate early protein nonstructural
IEP1 IE180 - - - - - - ICP4; gene regulation (transactivator); immediate early protein nonstructural
Ba5 IE180/LLT (2nd exon)     5.9 6.7 4.3   
LLTE222 LLT (2nd exon) - - - 6.8 8.9 8.2 not found unknown
RSP40 US1 - 5.3 8.3 12.9 15.3 13.0 RSP40/ICP22; unknown; HIV-1 homolog acts as regulator of gene expression nonstructural
PKNIA3 US3maj/US3min - - - - 6.0 5.0 PK, minor and major form of protein kinase; inhibits apoptosis tegument
GXGG US3maj/US3min/US4 - - 6.5 9.1 10.6 11.0   
GP50GD US6 - - - - - - gD; viral entry, type I membrane protein envelope
GP63GI US6/US7 - - - 5.0 6.3 8.5   
GIGE US8 - - - 4.0 - 4.3 gE; cell-cell spread envelope
11K2 US9/US8 - - - 9.0 10.0 10.4   
28KNIA3 US2 - - - 6.2 6.9 7.1 28K, tegument protein; membrane associated protein tegument
  1. *gene function and structural role [1] are only specified for amplicons that hybridize to a single transcript.
  2. - gene not found differentially expressed between PrV infected and mock-infected cells
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BMC Genomics

ISSN: 1471-2164

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