ORF1
|
ORF1
|
-
|
-
|
-
|
-
|
-
| |
unknown
|
virion
|
UL54
|
UL52/UL53/UL54
|
-
|
-
|
-
|
-
|
-
|
-
| | |
UL53
|
UL52/UL53
|
-
|
-
|
4.6
|
6.6
|
6.7
|
7.4
| | |
UL52
|
UL52
|
-
|
-
|
-
|
4.7
|
6.4
|
5.6
|
DNA replication; primase subunit of UL5/UL8/UL52complex
|
nonstructural
|
UL51
|
UL51
|
-
|
-
|
-
|
-
|
-
|
-
|
viral egress
|
tegument
|
UL50
|
UL50
|
-
|
-
|
-
|
-
|
-
|
-
|
dUTPase
|
nonstructural
|
UL49.5
|
UL49.5
|
-
|
4.4
|
6.4
|
9.0
|
10.4
|
13.5
|
gN; immune evasion (TAP inhibitor)
|
envelope
|
UL49
|
UL49.5/UL49
|
-
|
-
|
-
|
-
|
-
|
-
| | |
UL48
|
UL48
|
-
|
-
|
-
|
-
|
-
|
-
|
VP16, α-TIF; gene regulation(transactivator); viral egress
|
tegument
|
UL47
|
UL48/UL47
|
-
|
-
|
-
|
-
|
4.0
|
3.9
| | |
UL46
|
UL48/UL47/UL46
|
-
|
-
|
-
|
-
|
-
|
-
|
VP11/12; unknown; tegument protein
| |
GII
|
UL28/UL27
|
-
|
-
|
-
|
-
|
6.7
|
6.3
| | |
ICP18.5
|
UL28
|
-
|
-
|
-
|
-
|
-
|
7.4
|
ICP18,5; DNA cleavage and packaging; component of the UL15/UL28 terminase
|
capsid precursor
|
UL29
|
UL29
|
-
|
6.0
|
9.2
|
10.6
|
8.9
|
10.9
|
ICP8; DNA replication and recombination; binds ssDNA
|
nonstructural
|
UL30
|
UL30
|
-
|
-
|
4.2
|
-
|
-
|
-
|
DNA replication; DNA polymerase subunit of UL30/UL42 holoenzyme
|
nonstructural
|
UL31
|
UL32/UL31
|
-
|
-
|
-
|
4.5
|
9.2
|
10.1
| | |
UL32
|
UL32
|
-
|
-
|
-
|
-
|
4.0
|
4.1
|
DNA packaging; efficient localization of capsids to replication compartments
|
capsid precursor
|
UL33
|
UL33
|
-
|
-
|
-
|
-
|
4.5
|
5.8
|
DNA cleavage and packaging; associates with UL28 and UL15
|
nonstructural
|
UL34
|
UL33/UL34
|
-
|
-
|
-
|
-
|
6.1
|
5.0
| | |
UL35
|
UL33/UL34/UL35
|
-
|
-
|
5.6
|
7.1
|
9.5
|
9.5
| | |
UL361
|
UL36
|
-
|
-
|
-
|
-
|
-
|
-
|
VP1/2; viral egress(capsid tegumentation); interacts with Ul37 and capsid
|
tegument
|
UL362
|
UL36
|
-
|
-
|
-
|
-
|
-
|
3.8
|
VP1/2; viral egress(capsid tegumentation); interacts with Ul37 and capsid
|
tegument
|
UL37
|
UL37maj/UL37min
|
-
|
-
|
-
|
-
|
-
|
5.0
| | |
UL38
|
UL38
|
-
|
-
|
-
|
-
|
-
|
-
|
VP19c; minor capsid protein; UL38/UL18/UL18 triplex component
|
capsid
|
UL39
|
UL39
|
-
|
-
|
-
|
-
|
4.4
|
6.3
|
nucleotide synthesis; large subunit of ribonucleotide reductase
|
nonstructural
|
UL40
|
UL39/UL40
|
-
|
-
|
-
|
-
|
-
|
-
| | |
UL41
|
UL41
|
-
|
-
|
-
|
-
|
4.2
|
6.8
|
VHS, gene regulation; Rnase, degrades host and viral mRNAs
|
tegument
|
UL42
|
UL42
|
-
|
-
|
-
|
6.3
|
6.9
|
4.6
|
DNA replication; polymerase accessory subunit of UL30/UL42 holoenzyme
|
nonstructural
|
UL43
|
UL43
|
-
|
-
|
-
|
-
|
4.1
|
6.2
|
inhibits glycoprotein-mediated membrane fusion; type III membrane protein
|
envelope
|
GIIINIA3
|
UL44
|
-
|
-
|
-
|
8.2
|
12.7
|
13.9
|
gC; viral entry (virion attachment); type I membrane protein
|
envelope
|
ORF2NIA3
|
UL24/UL25/UL26/UL26.5
|
-
|
-
|
-
|
-
|
-
|
-
| | |
UL26NIA3
|
UL24/UL25/UL26
|
-
|
-
|
-
|
6.7
|
8.3
|
7.6
| | |
ORF1NIA3
|
UL24/UL25
| | | | |
8.1
|
8.0
| | |
UL25NIA3
|
UL24/UL25
|
-
|
-
|
-
|
8.3
|
10.7
|
12.2
| | |
UL24NIA3
|
UL24
|
-
|
-
|
-
|
6.9
|
9.8
|
10.4
|
unknown, type III membrane protein
|
unknown
|
TKNIA3
|
UL23
|
-
|
-
|
-
|
-
|
5.0
|
6.8
|
TK, nucleotide synthesis; thymidine kinase; selectively activates acyclovir
|
nonstructural
|
GHNIA3
|
UL22
|
-
|
-
|
4.8
|
6.0
|
8.8
|
9.0
|
gH; viral entry (fusion); cell-cell spread; type i membrane PT
|
envelope
|
UL21NIA3
|
UL21
|
-
|
-
|
-
|
-
|
5.9
|
5.5
|
unknown; capsid-associated tegument protein; interacts with UL16
|
tegument
|
UL20NIA3
|
UL20
|
-
|
-
|
-
|
3.8
|
5.3
|
7.3
|
viral egress, type III membrane protein
|
unknown
|
UL191
|
UL19maj/UL19min
|
-
|
-
|
-
|
5.0
|
9.7
|
10.8
| | |
UL192
|
UL19maj/UL19min
|
-
|
-
|
6.6
|
8.6
|
12.6
|
12.9
| | |
UL18
|
Ul19min/UL18
|
-
|
-
|
-
|
7.0
|
5.7
|
9.6
| | |
UL15EX2
|
UL15 (2nd exon)
|
-
|
-
|
6.4
|
6.5
|
7.5
|
9.2
|
DNA cleavage/encapsidation; terminase subunit of UL15/UL28 terminase6
|
capsid precursor
|
UL17
|
UL17
|
-
|
-
|
-
|
-
|
-
|
-
|
DNA cleavage and encapsidation
|
inner capsid
|
UL16
|
UL17/Ul16
|
-
|
-
|
-
|
4.5
|
6.2
|
5.0
| | |
UL15EX12
|
UL15 (1st exon)
|
-
|
-
|
-
|
-
|
4.0
|
7.7
|
DNA cleavage/encapsidation; terminase subunit of UL15/UL28 terminaseUL6
|
capsid precursor
|
UL14
|
UL14
| | | |
6.1
|
6.1
|
9.8
|
unknown
|
unknown
|
UL142
|
UL14
|
-
|
-
|
-
|
-
|
6.3
|
7.8
|
unknown
|
unknown
|
UL13
|
UL14/UL13
|
-
|
-
|
-
|
-
|
-
|
-
| | |
UL12
|
UL14/UL13/UL12
|
-
|
-
|
-
|
-
|
3.7
|
5.3
| | |
UL11
|
UL14/UL13/UL12/UL11
|
-
|
-
|
-
|
-
|
-
|
6.0
| | |
UL10
|
UL10
|
-
|
-
|
-
|
-
|
6.6
|
6.1
|
gM; inhibits glycoprotein-mediated membrane fusion; type III membrane protein
|
envelope
|
UL92
|
UL9
|
-
|
-
|
-
|
-
|
-
|
4.1
|
not found
|
non structural
|
UL8.5
|
UL9/UL8.5
|
-
|
-
|
-
|
4.0
|
-
|
-
| | |
UL8
|
UL9/UL8.5/UL8
|
-
|
-
|
-
|
-
|
-
|
-
| | |
UL7
|
UL6/UL7
|
-
|
-
|
5.0
|
7.4
|
10.7
|
9.4
| | |
UL6
|
UL6
|
-
|
-
|
5.0
|
12.7
|
13.8
|
13.3
|
capsid protein; portal protein; docking site for terminase
|
capsid
|
UL5
|
UL5
|
-
|
-
|
4.3
|
6.3
|
8.7
|
5.9
|
DNA replication; part of UL5/UL8/UL52 helicase/primase complex
|
nonstructural
|
UL4
|
UL5/UL4
|
-
|
-
|
-
|
-
|
3.5
|
5.5
|
unknown
| |
UL3.5
|
UL1/UL2/UL3/UL3.5
|
-
|
-
|
-
|
-
|
-
|
-
| | |
UL3
|
UL1/UL2/UL3
|
-
|
-
|
-
|
-
|
5.1
|
6.5
| | |
UL2
|
UL1/UL2
|
-
|
-
|
-
|
4.2
|
5.4
|
5.4
| | |
UL1
|
UL1
|
-
|
-
|
-
|
-
|
6.5
|
7.3
|
gL; viral entry (fusion); sell-sell spread
|
envelope
|
LLTE1
|
LLT (1st exon)
|
-
|
-
|
-
|
4.6
|
6.5
|
8.0
|
not found
|
unknown
|
EP02
|
EP0/LLT
|
-
|
-
|
-
|
-
|
-
|
-
| | |
EP01
|
EP0/LLT
|
-
|
-
|
-
|
-
|
6.3
|
4.7
| | |
LLTI2
|
LLT intron
|
-
|
-
|
-
|
-
|
3.7
|
4.7
| | |
LLTE21
|
LLT (2nd exon)
|
-
|
-
|
-
|
-
|
-
|
-
|
not found
|
unknown
|
IEP2
|
IE180
|
-
|
-
|
-
|
3.5
|
-
|
-
|
ICP4; gene regulation (transactivator); immediate early protein
|
nonstructural
|
IEP1
|
IE180
|
-
|
-
|
-
|
-
|
-
|
-
|
ICP4; gene regulation (transactivator); immediate early protein
|
nonstructural
|
Ba5
|
IE180/LLT (2nd exon)
| | | |
5.9
|
6.7
|
4.3
| | |
LLTE222
|
LLT (2nd exon)
|
-
|
-
|
-
|
6.8
|
8.9
|
8.2
|
not found
|
unknown
|
RSP40
|
US1
|
-
|
5.3
|
8.3
|
12.9
|
15.3
|
13.0
|
RSP40/ICP22; unknown; HIV-1 homolog acts as regulator of gene expression
|
nonstructural
|
PKNIA3
|
US3maj/US3min
|
-
|
-
|
-
|
-
|
6.0
|
5.0
|
PK, minor and major form of protein kinase; inhibits apoptosis
|
tegument
|
GXGG
|
US3maj/US3min/US4
|
-
|
-
|
6.5
|
9.1
|
10.6
|
11.0
| | |
GP50GD
|
US6
|
-
|
-
|
-
|
-
|
-
|
-
|
gD; viral entry, type I membrane protein
|
envelope
|
GP63GI
|
US6/US7
|
-
|
-
|
-
|
5.0
|
6.3
|
8.5
| | |
GIGE
|
US8
|
-
|
-
|
-
|
4.0
|
-
|
4.3
|
gE; cell-cell spread
|
envelope
|
11K2
|
US9/US8
|
-
|
-
|
-
|
9.0
|
10.0
|
10.4
| | |
28KNIA3
|
US2
|
-
|
-
|
-
|
6.2
|
6.9
|
7.1
|
28K, tegument protein; membrane associated protein
|
tegument
|