TY - JOUR AU - Bürglin, Thomas R. PY - 2008 DA - 2008/03/11 TI - Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif JO - BMC Genomics SP - 127 VL - 9 IS - 1 AB - The Hedgehog (Hh) signaling pathway plays important roles in human and animal development as well as in carcinogenesis. Hh molecules have been found in both protostomes and deuterostomes, but curiously the nematode Caenorhabditis elegans lacks a bona-fide Hh. Instead a series of Hh-related proteins are found, which share the Hint/Hog domain with Hh, but have distinct N-termini. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-9-127 DO - 10.1186/1471-2164-9-127 ID - Bürglin2008 ER -