Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif

Table 2 Components of the Hh signaling pathway in N. vectensis and Xiphinema sp. The absence of a gene does not mean it is not present, it just may not have been sequenced yet. Numbers indicate the protein prediction in JGI (Nv) or the accession number (XC). For more information on pathway components and C. elegans genes see [18]. Best blast scores are given for the Nv predictions in parenthesis.

# This match is to human KIF27, costa itself is rather divergent and may not be a bona-fide ortholog of KIF27, and there is functional divergence between mammals and Drosophila in this aspect of the pathway [42].
* best reciprocal match found is to Drosophila frizzled dFz2
** best reciprocal match found is to ULK3 kinase
*** best reciprocal match of Nv185528 is to fish protogenin 5e-75
1) mentioned in [25]
2) mentioned in [26]

ISSN: 1471-2164