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Table 2 Properties of skipped exons (S-exons) and exons with cryptic sites (C-exons). For all exon parameters the medians are reported. The last column reports parameters of all internal exons in our dataset of RefSeq genes. MW: the statistical significance of the differences between the S- and C-exons by the Mann-Witney test; n/s – non significant.

From: Computational analysis of splicing errors and mutations in human transcripts

  S-exons C-exons MW Internal exons
Set size
Mutated donor sites 67 42   
Mutated acceptor sites 42 72   
All 109 114   154846
Exon length (nucleotides)
Mutated donor sites 114 147 0,024  
Mutated acceptor sites 112,5 130 n/s  
All 114 136 0,020 123
Densities of cis-acting elements(candidate sites per nucleotide)
ESEfinder: SC35     
Mutated donor sites 0,043 0,042 n/s  
Mutated acceptor sites 0,038 0,045 n/s  
All 0,042 0,043 n/s 0,038
ESEfinder: SF2/ASF
Mutated donor sites 0,025 0,037 0,048  
Mutated acceptor sites 0,036 0,041 n/s  
All 0,028 0,040 0,005 0,036
ESEfinder: SRp40
Mutated donor sites 0,034 0,043 0,006  
Mutated acceptor sites 0,040 0,043 n/s  
All 0,035 0,043 0,004 0,040
ESEfinder: SRp55
Mutated donor sites 0,028 0,024 n/s  
Mutated acceptor sites 0,022 0,023 n/s  
All 0,025 0,023 n/s 0,023
RESCUE-ESE
Mutated donor sites 0,090 0,108 n/s  
Mutated acceptor sites 0,100 0,080 n/s  
All 0,091 0,094 n/s 0,099
PESE
Mutated donor sites 0,048 0,082 0,007  
Mutated acceptor sites 0,057 0,055 n/s  
All 0,055 0,064 0,023 0,064
PESS
Mutated donor sites 0,012 0,008 n/s  
Mutated acceptor sites 0,009 0,007 n/s  
All 0,011 0,007 n/s 0,007
Splice site scores
Mutated donor sites     
Authentic donor sites 18,52 18,49 n/s 18,82
Acceptor sites of the (upstream) exon 18,70 19,67 n/s 19,08
Acceptor sites of the (downstream) intron 19,37 18,98 n/s 19,09
Mutated acceptor sites
Authentic acceptor sites 19,59 18,72 0,05 19,08
Donor sites of the (downstream) exon 18,44 18,56 n/s 18,82
Donor sites of the (upstream) intron 18,48 18,51 n/s 18,79
Distance to the closest candidate site(nucleotides)
Mutated donor sites 220,5 75 0,067 289
Mutated acceptor sites 185 66 0,024 81