Table 2 Descriptive information on datasets extracted from the GEO database used in this study.
From: An indicator of cancer: downregulation of Monoamine Oxidase-A in multiple organs and species
Human Independent Samples (Case-control) | |||||||
|---|---|---|---|---|---|---|---|
GSE Number | GEO Description | Species | Control (N) | Cancer Type (N) | Mean Fold Difference in MAO-A | p-value | Percentage of cancer samples < lowest control |
GSE3189 | Cutaneous malignant melanoma | H | Normal (7) | Malignant Melanoma (45) | -15.0 | 4.9*10-21 | 100% |
GSE1037 | Lung neuroendocrine tumor classification | H | Normal Lung (19) | Small Cell lung Carcinoma (15) | -9.7 | 1.1*10-10 | 100% |
GSE2549* | Human Malignant Pleural Mesothelioma | H | Normal Pleura (5) | Malignant pleural mesothelioma (40) | -7.4 | 4.6*10-10 | 90% |
GSE61 | Breast tumor characterization | H | Normal Breast (10) | Basal-like Tumors (10) | -5.6 | 1.6*10-4 | 100% |
GSE2379 | Hypopharyngeal cancer at various stages of progression | H | Normal Uvula (3) | Early Stage (4) | -3.4 | 7.7*10-4 | 100% |
GSE3744 | Basal-like breast cancer tumors | H | Normal Breast (7) | Basal-like Cancer (18) | -5.7 | 0.002 | 88% |
* Lung tissue and cell lines were excluded. Only primary tumor samples and normal pleura were analyzed. | |||||||
Paired Samples | |||||||
GEO Series Number | Cancer Type | Species | Control (N) | Cancer (N) | Fold Difference in MAO-A | p-value | Percentage |
GSE3268 | Human Squamous Cell Carcinoma of the lung | H | Control (5) | Cancer (5) | -2.7 | 0.001 | 100% |
GSE781 | Clear Cell Carcinoma of the human kidney | H | Normal (7) | Renal clear Cell Carcinoma (7) | -2.2 | 0.002 | 100% |
GSE2514 | Pulmonary adenocarcinoma | H | Adjacent Normal (10) | Tumor (10) | -1.7 | 0.004 | 80% |
GSE2685** | Gastric cancer | H | Normal (6) | Cancer (6) | -3.6 | 0.03§ | 100% |
GSE3678 | Papillary thyroid cancer | H | Normal (7) | Papillary thyroid Cancer (7) | -1.2 | 0.08§ | 71% |
GSE3467 | Papillary thyroid cancer | H | Normal (9) | Papillary thyroid Carcinoma (9) | -1.1 | 0.286§ | 67% |
**Paired data was extracted and unpaired samples were excluded. | |||||||
Animal Models | |||||||
GEO Series Number | Cancer Type | Species | Control (N) | Cancer (N) | Fold Difference in MAO-A | p-value | Percentage |
GSE2514 | Urethane-induced lung tumor model of pulmonary adenocarcinoma | M | Adjacent Normal (10) | Tumor (29) | -1.7 | 6.6*10-10 | 86% |
GSE3519*** | Liver cancer model | Z | Normal Liver Tissue (10) | Liver Tumor (10) | -2.2 | 1.7*10-5 | 100% |
GSE3348 | LH overexpressing virgin mice (luteinizing hormone overexpression causes spontaneous mammary tumors) | M | Wild type Breast tissue (3) | LH-overexpressing Breast tissue (3) | -1.7 | 5.9*10-5 | 100% |
GSE2426 | Patched heterozygous model of medulloblastoma | M | Granule cell Precursor (4) | Tumor Cells from Heterozygotes (5) | -1.6 | 6.9*10-5 | 100% |
GSE422 | Colon cancer | M | C57/BL6 wild-type (6) | APC(Min/+) mutant (10) | -18.9 | 1.1*10-4 | 100% |
GSE1872**** | N-methyl-N-nitrosourea-induced breast cancer model (R) | R | Normal (11) | Cancer (9) | -1.7 | 5.9*10-5 | 100% |
GSE2528 | Mammary tumorigenesis in MMTV-neu model | M | Wild type Normal Breast (3) | Mammary tumors in MMTV-neu Model (7) | -1.8 | 0.001 | 100% |