Figure 1From: Topological comparison of methods for predicting transcriptional cooperativity in yeastExamples of the calculation of the functional similarity score. Transcription factors are represented as TF1, TF2 and TF3. The group of genes regulated by each TF are GTF1 = {A, B, C}, GTF2 = {D, E, F} and GTF3 = {G, D, H, I}. The five different protein functions in this simplified figure are labeled as f a ...f e . The functions are associated to the genes with an arrow. In this example, we calculated the functional similarity score of TF1-TF2, TF1-TF3 and TF3-TF3. The last two examples show how the FS score deals with similar functional profiles.Back to article page