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Figure 1 | BMC Genomics

Figure 1

From: Topological comparison of methods for predicting transcriptional cooperativity in yeast

Figure 1

Examples of the calculation of the functional similarity score. Transcription factors are represented as TF1, TF2 and TF3. The group of genes regulated by each TF are GTF1 = {A, B, C}, GTF2 = {D, E, F} and GTF3 = {G, D, H, I}. The five different protein functions in this simplified figure are labeled as f a ...f e . The functions are associated to the genes with an arrow. In this example, we calculated the functional similarity score of TF1-TF2, TF1-TF3 and TF3-TF3. The last two examples show how the FS score deals with similar functional profiles.

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