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Table 7 Out-degree modularity in the regulatory network

From: Topological comparison of methods for predicting transcriptional cooperativity in yeast

 

CTFPs

Co-functional TF pairs

Co-regulatory TF pairs

Co-functional ∩ co-regulatory TF pairs

Random TF pairs

Method

Mean

Mean

p-value

Mean

p-value

Mean

p-value

Mean

p-value

Method N

0.424

0.132

1.986·10-11

0.318

1.496·10 -1

0.590

1.992·10-3

0.050

2.200·10-16

Method B

0.314

0.132

8.341·10-7

0.318

7.463·10 -1

0.590

1.170·10-4

0.050

3.553·10-15

Method T

0.300

0.132

6.995·10-5

0.318

8.042·10 -1

0.590

1.210·10-3

0.050

5.072·10-9

Method C

0.314

0.132

3.756·10-12

0.318

8.524·10 -1

0.590

5.027·10-5

0.050

2.200·10-16

  1. Out-degree modularity of cooperative TF pairs in the regulatory network. The out-degree of a gene denotes the regulatory control performed by that gene upon the expression of other genes. Modularity was measured as topological overlap (see Methods). The distribution of modularity values for the CTFPs predicted by each method was compared to distributions in the other sets of TF pairs by means of a Mann-Whitney test. Font styles are as in Table 3.
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BMC Genomics

ISSN: 1471-2164

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