Table 3 List of top 20 up and down regulated genes in the head kidney of trout, 24 and 72 hours after i.p. injection of active IHNV. Genes were selected for significant differential expression at p < 0.01 (FDR < 0.05). Values are expressed as FC, fold change.
24 hours UP | Â | Â | Â | 72 hours UP | Â | Â | Â |
|---|---|---|---|---|---|---|---|
Clone ID | Clone Name | FC | p | Clone ID | Clone Name | FC | p |
CA343473 | C3a anaphylatoxin chemotactic receptor | 5.35 | 0.000 | HST0001_D04 | Alpha-globin I-2 | 15.48 | 0.000 |
est04c02 | Unknown-53 | 4.26 | 0.000 | est02a11 | Ig kappa chain V-IV region B17-2 | 10.06 | 0.000 |
est02b02 | PEST-containing nuclear protein | 4.00 | 0.000 | EXOB4_D02 | Beta actin-2 | 9.60 | 0.000 |
EXOB3_A01 | Unknown-103 | 3.91 | 0.000 | EXOB2_B10 | Hemoglobin beta chain | 9.58 | 0.000 |
CA358107 | Ectonucleoside triphosphate diphosphohydrolase 1 | 3.69 | 0.000 | HK0003_A03 | Thymosin beta-4-2 | 7.56 | 0.000 |
EXOB4_H01 | Unknown-132 | 3.63 | 0.000 | est02f08 | Serine protease-like protein-1 | 6.41 | 0.000 |
HK0002_G04 | Fructose-bisphosphate aldolase A | 3.59 | 0.000 | est02h09 | Nonhistone chromosomal protein HMG-17 | 6.00 | 0.000 |
EXOB1_B03 | Unknown-81 | 3.59 | 0.000 | est03c04 | Matrix metalloproteinase-9 | 5.91 | 0.000 |
EXOB4_E09 | Hypoxanthine-guanine phosphoribosyltransferase | 3.55 | 0.000 | est01e06 | Coronin-1B | 5.51 | 0.000 |
CA378361 | Ubiquitin ligase SIAH1 | 3.43 | 0.000 | est02g07 | Ig mu heavy chain disease protein | 5.44 | 0.000 |
HK0003_G05 | Unknown-201 | 3.43 | 0.000 | EXOB4_H05 | Unknown-133 | 5.24 | 0.000 |
est04f10 | Hypothetical-fish 1 | 3.41 | 0.000 | est01e02 | Thymosin beta-4-1 | 5.17 | 0.000 |
EST1-3A_G03 | Unknown-74 | 3.40 | 0.000 | EXOB3_D02 | Eukaryotic translation elongation factor 1 alpha 1 | 4.60 | 0.000 |
CA378435 | Protein phosphatase 2C delta isoform | 3.35 | 0.000 | EXOB2_A01 | MHC class II invariant chain-like protein 1 | 4.44 | 0.000 |
HK0002_H10 | Unknown-182 | 3.33 | 0.000 | EXOB3_H01 | Matrix metalloproteinase-13 | 4.34 | 0.000 |
EXOB1_F02 | Transcription regulator protein BACH1 | 3.28 | 0.000 | EXOB1_A05 | Ribosomal protein L6-1 | 4.33 | 0.000 |
est04b01 | Similar to rRNA (Vangl2) | 3.26 | 0.000 | EST1-3A_F05 | Heat shock 70 kDa protein 1 | 4.27 | 0.000 |
EST1-3A_H05 | Adenosine deaminase 3 | 3.21 | 0.000 | EXOB2_G0 | Profilin-1 | 4.00 | 0.000 |
HK0001_H12 | Unknown-162 | 3.05 | 0.000 | HKT0001_H03 | Microtubule-associated protein RP/EB | 3.95 | 0.000 |
CA368716 | Membrane-bound transcription factor site 2 protease | 3.00 | 0.000 | CA370329 | Lysozyme C precursor | 3.91 | 0.000 |
24 hours DOWN | Â | Â | Â | 72 hours DOWN | Â | Â | Â |
utu01a03 | 40S ribosomal protein S3-1 | -3.22 | 0.000 | EXOB1_B02 | Hypothetical-fish 34 | -4.48 | 0.000 |
HKT0001_H03 | Microtubule-associated protein RP/EB | -3.24 | 0.000 | HK0002_G04 | Fructose-bisphosphate aldolase A | -4.80 | 0.000 |
utu04g05 | 40S ribosomal protein S9-3 | -3.27 | 0.000 | CA384134 | G1/S-specific cyclin D2 | -4.93 | 0.000 |
EST1-3A_D03 | 60S ribosomal protein L23 | -3.32 | 0.000 | EST1-3A_H03 | Unknown-76 | -5.18 | 0.000 |
EXOB1_H08 | ADP, ATP carrier protein 3 | -3.43 | 0.000 | est03f04 | F-box/WD-repeat protein 11 | -5.28 | 0.000 |
EST1-3A_F05 | Heat shock 70 kDa protein 1 | -3.54 | 0.000 | CA368716 | Membrane-bound transcription factor site 2 protease | -5.31 | 0.000 |
EXOB1_A03 | Metallothionein A | -3.55 | 0.000 | CA384029 | Chromobox protein homolog 4 | -5.47 | 0.000 |
EXOB2_G09 | Cytochrome c oxidase subunit I-2 | -3.55 | 0.000 | EXOB3_A01 | Unknown-103 | -5.54 | 0.000 |
HST0001_C03 | Plasminogen precursor-2 | -3.56 | 0.000 | EXOB4_H01 | Unknown-132 | -5.99 | 0.000 |
EXOB3_E01 | Na/K ATPase alpha subunit-2 | -3.76 | 0.000 | EST1-3A_H05 | Adenosine deaminase 3 | -6.23 | 0.000 |
HK0001_D01 | Ubiquitin | -3.83 | 0.000 | EXOB1_B03 | Unknown-81 | -6.29 | 0.000 |
HK0002_B07 | Heat shock 70kDa protein 8 | -4.24 | 0.000 | HK0001_H12 | Unknown-162 | -6.44 | 0.000 |
Hete0002_A07 | Metallothionein-IL | -4.50 | 0.000 | HK0002_H10 | Unknown-182 | -6.59 | 0.000 |
utu02a08 | Ubiquitin and ribosomal protein S27a-2 | -4.43 | 0.000 | est04c02 | Unknown-53 | -6.62 | 0.000 |
est02a11 | Ig kappa chain V-IV region B17-2 | -4.84 | 0.000 | EXOB4_E09 | Hypoxanthine-guanine phosphoribosyltransferase | -6.63 | 0.000 |
utu02c02 | Myosin heavy chain, skeletal, adult 1-1 | -4.97 | 0.000 | est02b02 | PEST-containing nuclear protein | -6.85 | 0.000 |
utu04f11 | 40S ribosomal protein S3-2 | -6.00 | 0.000 | est04f10 | Hypothetical-fish 1 | -7.01 | 0.000 |
est03c10 | Alanine-glyoxylate aminotransferase 2 | -7.41 | 0.000 | EST1-3A_G03 | Unknown-74 | -7.55 | 0.000 |
est01c04 | Unknown-11 | -8.11 | 0.000 | CA378361 | Ubiquitin ligase SIAH1 | -7.82 | 0.000 |
HK0002_D07 | Unknown-172 | -8.74 | 0.000 | EXOB2_G11 | Stanniocalcin-1 | -9.69 | 0.000 |