Skip to main content

Table 3 GO categories with high protein conservation. Terms of biological process are labeled as P, cellular component as C, molecular function as F.

From: Weak correlation between sequence conservation in promoter regions and in protein-coding regions of human-mouse orthologous gene pairs

GO term

Number of genes

P-value

F:GTPase activity

88

0

F:GTP binding

160

0

P:intracellular transport

350

0

P:small GTPase mediated signal transduction

126

1.11E-16

F:RNA binding

290

1.33E-15

C:cytosol

171

3.70E-11

P:RNA processing

198

3.25E-10

C:Golgi apparatus

216

5.63E-10

P:intracellular signaling cascade

431

2.57E-09

C:spliceosome complex

37

6.46E-09

P:transcription

640

1.76E-08

P:regulation of transcription

602

2.02E-08

F:ATP binding

520

2.85E-08

C:actin cytoskeleton

85

5.37E-08

P:vesicle-mediated transport

190

7.02E-08

P:cytoskeleton organization and biogenesis

155

9.26E-08

F:cytoskeletal protein binding

137

1.44E-07

P:secretory pathway

102

7.91E-07

C:nucleoplasm

107

1.22E-06

C:ribosome

114

1.36E-06

P:protein biosynthesis

283

1.56E-06

P:ubiquitin cycle

235

2.86E-06

F:ion channel activity

98

7.08E-05

P:protein amino acid phosphorylation

213

0.000101

F:ATPase activity

130

0.000143

C:endomembrane system

163

0.000154

F:protein kinase activity

220

0.000178

P:nervous system development

154

0.000293

F:transcription factor activity

263

0.000465

C:microtubule cytoskeleton

115

0.000595

C:vesicle

86

0.000732

F:structural molecule activity

307

0.000801

F:structural constituent of ribosome

130

0.000843

F:ubiquitin-protein ligase activity

144

0.001969

C:organelle membrane

242

0.004122

P:cell cycle

340

0.006445