Ingenuity™ Pathway gene network. The most highly significant gene network identified in the Ingenuity™ Pathway analysis of our Affymetrix microarray data is shown. An additional 11 'custom' genes were placed into this network based on new information available in the recent literature. Many of the key genes highlighted in this top network are members of the ontology group that includes receptors, ligands and interacting proteins found in the cubilin-megalin multiligand endocytic receptor complex. The networks are displayed graphically as nodes (genes/gene products) and edges (the biological relationships between the nodes). The intensity of the node color indicates the degree of up- (red) or down- (green) regulation in gene expression in our microarray analysis. Nodes are displayed using various shapes that represent the functional class of the gene product. Edges are displayed as a direct interaction (solid line) or as an indirect/unknown interaction (dashed line). The nodes have also been arranged to show the location of the gene/gene product with respect to cellular or subcellular localization (e.g. plasma membrane, cytoplasm, nucleus, etc.).