Strand bias structure in mouse DNA gives a glimpse of how chromatin structure affects gene expression

BMC Genomics

Table 2 Number of genes – comparisons with hybrid genome – upstream versus downstream

	Genome	Number of TSSs upstream	Number of TSSs downstream	Total	Proportion
	i	ii	iii	iv = ii + iii	v = iii/iv
A	real	5738	10033	15771	63.6%
B	hybrid	3791	6072	9863	61.6%
C	A – B	1947	3961	5908	67.0% (X)

Columns ii and iii refer to the number of TSSs within 100 kb of the A+/T+ boundary, upstream or downstream respectively. The figure of 67.0% (X) is significantly different from 50.0% using a binomial distribution approximated by the normal distribution, p < 10^-50, n = 5908, z = 26, one tailed test.

ISSN: 1471-2164