|
Stimulation
| |
No. of genes
| |
|---|
| |
Total
|
Positive regulationb
|
Negative regulationb
|
|---|
|
None
|
93
|
43
|
50
|
|
Anti-CD3
|
129
|
45
|
84
|
|
Anti-CD3+anti-CD28
|
203
|
173
|
30
|
- a Genes were classified as PARP-1 dependent genes when their expression was change by a factor of at least 1.5 (F-test<0.05) between Parp-1+/+ and Parp-1-/- cells in the microarrays analysis. bPositive regulation was considered when the expression of a particular gene was higher in the presence of PARP-1 than in its absence. Likewise, genes expressed at higher level in the absence of PARP-1 than in its presence were considered negatively regulated by PARP-1.
