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Table 1 Functional classification of HK408 genes

From: How many human genes can be defined as housekeeping with current expression data?

Function Pathway/Complexa # Genes MA18b MA16 EST18 EST16
Transcription Transcription pre-initiation complex 40 3 13 12 28
  Basal transcription elongation factor 17 4 7 5 15
  Capping, splicing and polyadenylation 99 42 55 72 96
Transport Nuclear pore complex 29 2 4 10 26
Translation Basal translation factor 37 20 28 30 37
  tRNA synthetase 20 8 13 19 20
  Cytosolic ribosome 82 79 79 78 81
Proteolysis Ubiquitin mediated proteolysis 45 8 12 22 40
  Proteasome 43 17 26 31 41
Total   408 182 235 278 379
  1. a 408 genes with highly proposed housekeeping functions are manually curated from Reactome [20] and KEGG [21].
  2. b The column MA18 and MA16 represent the number of these HK genes detected in all 18 tissues and at least 16 tissues by microarray data, respectively; EST18 and EST16 represent that for EST data.