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Table 1 Functional classification of HK408 genes

From: How many human genes can be defined as housekeeping with current expression data?

Function

Pathway/Complexa

# Genes

MA18b

MA16

EST18

EST16

Transcription

Transcription pre-initiation complex

40

3

13

12

28

 

Basal transcription elongation factor

17

4

7

5

15

 

Capping, splicing and polyadenylation

99

42

55

72

96

Transport

Nuclear pore complex

29

2

4

10

26

Translation

Basal translation factor

37

20

28

30

37

 

tRNA synthetase

20

8

13

19

20

 

Cytosolic ribosome

82

79

79

78

81

Proteolysis

Ubiquitin mediated proteolysis

45

8

12

22

40

 

Proteasome

43

17

26

31

41

Total

 

408

182

235

278

379

  1. a 408 genes with highly proposed housekeeping functions are manually curated from Reactome [20] and KEGG [21].
  2. b The column MA18 and MA16 represent the number of these HK genes detected in all 18 tissues and at least 16 tissues by microarray data, respectively; EST18 and EST16 represent that for EST data.